The emerging role of TH17 cells in organ transplantation

Jeremy A. Sullivan, Andrew B. Adams, William J. Burlingham

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

While transplantation research continues to focus on the development of Treg-sparing and plasma cell/B-cell-targeting strategies to improve long-term outcomes, little attention has been paid to the emerging role of the TH17 cell in mediating chronic rejection. This review aimed to summarize the recent emergence of the TH17 and the newly described TH1/17 cell as major players in transplantation and to suggest ways of improving graft outcome through TH17-targeted immunosuppression.

Original languageEnglish (US)
Pages (from-to)483-489
Number of pages7
JournalTransplantation
Volume97
Issue number5
DOIs
StatePublished - Mar 15 2014
Externally publishedYes

Keywords

  • Collagen type V
  • IL-23
  • Monocytes
  • P2X7
  • TH17
  • Transplantation

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