The effects of zinc amino acid complex supplementation on the porcine host response to Lawsonia intracellularis infection

Fernando L. Leite, Erika Vasquez, Fabio A. Vannucci, Connie J. Gebhart, Aaron Rendahl, Jerry Torrison, Adam Mueller, Nathan L. Winkelman, Zachary J. Rambo, Richard E. Isaacson

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Lawsonia intracellularis is among the most important enteric pathogens of swine and antibiotic alternatives are needed to help mitigate the negative effects of infection. Zinc is an essential trace mineral known to be crucial for maintaining intestinal barrier function and proper immune response. In this study, we investigated the porcine host response to L. intracellularis infection when supplemented with a zinc-amino acid complex, a form of zinc that can lead to greater bioavailability when compared to traditional inorganic forms of zinc. Our results show that a zinc-amino acid complex supplementation with a final concentration of 125 ppm of zinc in feed significantly (p < 0.05) decreased the number of animals with lesions and severity of lesions caused by L. intracellularis. Animals supplemented with the zinc-amino acid complex also exhibited a significantly (p < 0.05) earlier onset of seroconversion as well as an increased number of T cells in infected and non-infected intestinal tissue. This study demonstrated that this zinc-amino acid complex aids the host in responding to L. intracellularis infection and may be a new approach to help minimize negative effects of disease.

Original languageEnglish (US)
Article number88
JournalVeterinary research
Issue number1
StatePublished - Sep 10 2018

Bibliographical note

Funding Information:
This project was funded by a grant from Zinpro Corporation. Zinpro Corporation contributed to the design of the study and editing of the manuscript but was not involved in collection, analysis, and interpretation of data.

Publisher Copyright:
© 2018 The Author(s).


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