TY - JOUR
T1 - The Effects of the Inhalational Anesthetic Agent Combination, Isoflurane–Nitrous Oxide, on Survival in a Pig Random Skin Flap Model
AU - Dohar, Joseph E.
AU - Goding, George S.
AU - Maisel, Robert H.
N1 - Funding Information:
AcceptedforpublicationFebruary1, 1993. This study was supported by a grant from the Min¬
PY - 1994/1
Y1 - 1994/1
N2 - Using a dorsally based, random skin flap model in 14 swine, the influence on skin flap survival of isoflurane used with nitrous oxide as maintenance anesthetic agents was examined. The mean area of skin flap survival was 54.9% for the experimental group compared with 28.6% in the control group. Arterial blood gas content (Po2, Pco2, and HCO3−), respiratory rate, acid-base balance, blood pressure level, pulse rate, and temperature were monitored. Improved survival of the isoflurane–nitrous oxide group was independent of these parameters. These data support the findings of a previous study that isoflurane positively affects random skin flap survival in a swine model. Furthermore, the addition of nitrous oxide partially reduces isoflurane'S beneficial effects.
AB - Using a dorsally based, random skin flap model in 14 swine, the influence on skin flap survival of isoflurane used with nitrous oxide as maintenance anesthetic agents was examined. The mean area of skin flap survival was 54.9% for the experimental group compared with 28.6% in the control group. Arterial blood gas content (Po2, Pco2, and HCO3−), respiratory rate, acid-base balance, blood pressure level, pulse rate, and temperature were monitored. Improved survival of the isoflurane–nitrous oxide group was independent of these parameters. These data support the findings of a previous study that isoflurane positively affects random skin flap survival in a swine model. Furthermore, the addition of nitrous oxide partially reduces isoflurane'S beneficial effects.
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U2 - 10.1001/archotol.1994.01880250066009
DO - 10.1001/archotol.1994.01880250066009
M3 - Article
C2 - 8274259
AN - SCOPUS:0028069362
SN - 0886-4470
VL - 120
SP - 74
EP - 77
JO - Archives of Otolaryngology--Head and Neck Surgery
JF - Archives of Otolaryngology--Head and Neck Surgery
IS - 1
ER -