The effects of silver nanoparticles on behavior, apoptosis and nitro-oxidative stress in offspring Wistar rats

Oana Ofelia Dǎnilǎ, Alexandra Sevastre Berghian, Vlad Dionisie, Dan Gheban, Diana Olteanu, Flaviu Tabaran, Ioana Baldea, Gabriel Katona, Bianca Moldovan, Simona Clichici, Luminita David, Gabriela Adriana Filip

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Aim: To investigate the comparative effects of prenatal exposure to silver nanoparticles (AgNPs) functionalized with citrate and polyphenols on spatial cognition and also on nitro-oxidative stress and apoptosis in the hippocampus and cerebellum of offsprings. Materials & methods: Pregnant Wistar rats were orally administered substances from day 10 of gestation until day 21. Six weeks postpartum, six male offsprings from each group were used for behavioral evaluation and determination of oxidative stress and apoptosis. Results: Both groups exhibited hyperactivity and anxiety especially after AgNPs-Sambucus nigra L. administration. AgNPs-S. nigra L. group showed increase in induced nitric oxide synthase activity and decrease in superoxide dismutase activity and apoptosis in the hippocampus, while AgNPs-citrate coated administration exerted a moderate toxicity and induced apoptosis. Conclusion: AgNPs functionalized with natural extracts had a lower toxicity than citrate-coated silver particles.

Original languageEnglish (US)
Pages (from-to)1455-1473
Number of pages19
JournalNanomedicine
Volume12
Issue number12
DOIs
StatePublished - Jun 2017

Keywords

  • apoptosis
  • cerebellum
  • hippocampus
  • nitro-oxidative stress
  • polyphenols
  • silver nanoparticles

PubMed: MeSH publication types

  • Journal Article

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