The effects of recombinant human lactoferrin on immune activation and the intestinal microbiome among persons living with human immunodeficiency virus and receiving antiretroviral therapy

Ornella Sortino, Katherine Huppler Hullsiek, Elizabeth Richards, Adam Rupert, Andrea Schminke, Namo Tetekpor, Mariam Quinones, Rachel Prosser, Tim Schacker, Irini Sereti, Jason V. Baker

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Lactoferrin modulates mucosal immunity and targets mechanisms contributing to inflammation during human immunodeficiency virus disease. A randomized placebo-controlled crossover clinical trial of recombinant human (rh) lactoferrin was conducted among 54 human immunodeficiency virus-infected participants with viral suppression. Outcomes were tolerability, inflammatory, and immunologic measures, and the intestinal microbiome. The median age was 51 years, and the median CD4+ cell count was 651/μ L. Adherence and adverse events did not differ between rh-lactoferrin and placebo. There was no significant effect on plasma interleukin-6 or D-dimer levels, nor on monocyte/T-cell activation, mucosal integrity, or intestinal microbiota diversity. Oral administration of rh-lactoferrin was safe but did not reduce inflammation and immune activation.

Original languageEnglish (US)
Pages (from-to)1963-1968
Number of pages6
JournalJournal of Infectious Diseases
Volume219
Issue number12
DOIs
StatePublished - Jun 1 2019

Keywords

  • HIV
  • Immune activation
  • Inflammation
  • Lactoferrin
  • Microbiome

PubMed: MeSH publication types

  • Clinical Trial
  • Journal Article
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

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