The effects of intravaginal clindamycin and metronidazole therapy on vaginal Mobiluncus morphotypes in patients with bacterial vaginosis

Paul Nyirjesy, Matthew J. McIntosh, Jana I. Steinmetz, Robert J Schumacher, James L. Joffrion

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

OBJECTIVE: The objective of this study was to compare the effects of treatments for bacterial vaginosis (BV) on vaginal Mobiluncus morphotypes. STUDY DESIGN: Analyses were performed on Mobiluncus scores from similarly conducted studies evaluating clindamycin vaginal single-dose cream (CVSDC) or metronidazole vaginal gel (MVG) in 55 patients with BV and with Mobiluncus morphotypes at baseline. RESULTS: Both treatment groups demonstrated significant reductions in Mobiluncus score. However, the Mobiluncus score at test-of-cure was lower in the CVSDC than in the MVG group (P = 0.0471). More patients in the CVSDC group than in the MVG group achieved microbiologic (57.5% vs. 26.7%; P = 0.04), clinical (57.5% vs. 26.7%; P = 0.04), and therapeutic cures of BV (45.0% vs. 20.0%; P = 0.09). CONCLUSION: Clindamycin reduces vaginal Mobiluncus morphotypes to a greater extent than metronidazole in patients with BV; this correlates with a higher BV cure rate.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalSexually Transmitted Diseases
Volume34
Issue number4
DOIs
StatePublished - Apr 1 2007

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