The effects of intermittent nitrogen dioxide exposure on vitamin E-deficient and -sufficient rats

A. Saari Csallany; K. Lund Ayaz

doi:10.1016/0378-4274(78)90080-2

The effects of intermittent nitrogen dioxide exposure on vitamin E-deficient and -sufficient rats

A. Saari Csallany, K. Lund Ayaz

Research output: Contribution to journal › Article › peer-review

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Abstract

In two separate experiments rats fed vitamin E-deficient, normal or high vitamin E-supplemented diets were intermittently exposed to 15 ppm ± 1.0 ppm nitrogen dioxide (NO₂) over a 5-week (4 days/week, total of 31.5 h exposure) or an 18-week (5 days/week, total of 93.5 h exposure) period. In the 5-week, NO₂-exposed rats, the blood methemoglobin levels were not influenced by NO₂ exposure or the level of vitamin E in the diet. Tissues of the rats exposed to NO₂ for 18 weeks showed some histological changes; in the lung, increased atelectasis and alveolar thickening and in the liver, increased granular changes, karyolysis and karyorhexis. These differences were suppressed by increasing levels of dietary vitamin E. Tissue lipofuscin pigment (LFP) concentrations were not affected by NO₂ exposure or dietary vitamin E. Fatty acid distribution of lung lipid extracts showed no changes due to NO₂ exposure; however, some effects of dietary vitamin E could be seen. The results suggest that intermittent NO₂ exposure, under the described conditions, did not cause ultimate changes of the biochemical parameters measured.

Original language	English (US)
Pages (from-to)	97-107
Number of pages	11
Journal	Toxicology Letters
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/0378-4274(78)90080-2
State	Published - Jul 1978

Bibliographical note

Funding Information:
The authors gratefully acknowledge the histological examination of tissues performed by Dr. P.D. Beamer, Professor of Pathology, College of Veterinary Medicine, University of Illinois, Urbana, and the gasc hromatographic analyses performed by Dr. J.G. Bieri, Director Nutrition Biochemistry Section, Natl. Inst. Arth., Metab. and Digestive Diseases,N IH, Bethesda, Maryland. This researchw as supported by USPHS Grant No. 1 01 ES01057-01 and the Minnesota Agricultural Experiment Station (Paper No. 10132).

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title = "The effects of intermittent nitrogen dioxide exposure on vitamin E-deficient and -sufficient rats",

abstract = "In two separate experiments rats fed vitamin E-deficient, normal or high vitamin E-supplemented diets were intermittently exposed to 15 ppm ± 1.0 ppm nitrogen dioxide (NO2) over a 5-week (4 days/week, total of 31.5 h exposure) or an 18-week (5 days/week, total of 93.5 h exposure) period. In the 5-week, NO2-exposed rats, the blood methemoglobin levels were not influenced by NO2 exposure or the level of vitamin E in the diet. Tissues of the rats exposed to NO2 for 18 weeks showed some histological changes; in the lung, increased atelectasis and alveolar thickening and in the liver, increased granular changes, karyolysis and karyorhexis. These differences were suppressed by increasing levels of dietary vitamin E. Tissue lipofuscin pigment (LFP) concentrations were not affected by NO2 exposure or dietary vitamin E. Fatty acid distribution of lung lipid extracts showed no changes due to NO2 exposure; however, some effects of dietary vitamin E could be seen. The results suggest that intermittent NO2 exposure, under the described conditions, did not cause ultimate changes of the biochemical parameters measured.",

author = "Csallany, \{A. Saari\} and Ayaz, \{K. Lund\}",

note = "Funding Information: The authors gratefully acknowledge the histological examination of tissues performed by Dr. P.D. Beamer, Professor of Pathology, College of Veterinary Medicine, University of Illinois, Urbana, and the gasc hromatographic analyses performed by Dr. J.G. Bieri, Director Nutrition Biochemistry Section, Natl. Inst. Arth., Metab. and Digestive Diseases,N IH, Bethesda, Maryland. This researchw as supported by USPHS Grant No. 1 01 ES01057-01 and the Minnesota Agricultural Experiment Station (Paper No. 10132).",

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T1 - The effects of intermittent nitrogen dioxide exposure on vitamin E-deficient and -sufficient rats

AU - Csallany, A. Saari

AU - Ayaz, K. Lund

N1 - Funding Information: The authors gratefully acknowledge the histological examination of tissues performed by Dr. P.D. Beamer, Professor of Pathology, College of Veterinary Medicine, University of Illinois, Urbana, and the gasc hromatographic analyses performed by Dr. J.G. Bieri, Director Nutrition Biochemistry Section, Natl. Inst. Arth., Metab. and Digestive Diseases,N IH, Bethesda, Maryland. This researchw as supported by USPHS Grant No. 1 01 ES01057-01 and the Minnesota Agricultural Experiment Station (Paper No. 10132).

PY - 1978/7

Y1 - 1978/7

N2 - In two separate experiments rats fed vitamin E-deficient, normal or high vitamin E-supplemented diets were intermittently exposed to 15 ppm ± 1.0 ppm nitrogen dioxide (NO2) over a 5-week (4 days/week, total of 31.5 h exposure) or an 18-week (5 days/week, total of 93.5 h exposure) period. In the 5-week, NO2-exposed rats, the blood methemoglobin levels were not influenced by NO2 exposure or the level of vitamin E in the diet. Tissues of the rats exposed to NO2 for 18 weeks showed some histological changes; in the lung, increased atelectasis and alveolar thickening and in the liver, increased granular changes, karyolysis and karyorhexis. These differences were suppressed by increasing levels of dietary vitamin E. Tissue lipofuscin pigment (LFP) concentrations were not affected by NO2 exposure or dietary vitamin E. Fatty acid distribution of lung lipid extracts showed no changes due to NO2 exposure; however, some effects of dietary vitamin E could be seen. The results suggest that intermittent NO2 exposure, under the described conditions, did not cause ultimate changes of the biochemical parameters measured.

AB - In two separate experiments rats fed vitamin E-deficient, normal or high vitamin E-supplemented diets were intermittently exposed to 15 ppm ± 1.0 ppm nitrogen dioxide (NO2) over a 5-week (4 days/week, total of 31.5 h exposure) or an 18-week (5 days/week, total of 93.5 h exposure) period. In the 5-week, NO2-exposed rats, the blood methemoglobin levels were not influenced by NO2 exposure or the level of vitamin E in the diet. Tissues of the rats exposed to NO2 for 18 weeks showed some histological changes; in the lung, increased atelectasis and alveolar thickening and in the liver, increased granular changes, karyolysis and karyorhexis. These differences were suppressed by increasing levels of dietary vitamin E. Tissue lipofuscin pigment (LFP) concentrations were not affected by NO2 exposure or dietary vitamin E. Fatty acid distribution of lung lipid extracts showed no changes due to NO2 exposure; however, some effects of dietary vitamin E could be seen. The results suggest that intermittent NO2 exposure, under the described conditions, did not cause ultimate changes of the biochemical parameters measured.

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The effects of intermittent nitrogen dioxide exposure on vitamin E-deficient and -sufficient rats

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