TY - JOUR
T1 - The effects of glucagon-like peptide-i (glp-i) on hormone secretion from isolated human pancreatic islets
AU - Fehmann, Hans Christoph
AU - Hering, Bernd Josef
AU - Wolf, Markus Joachim
AU - Brandhorst, Heide
AU - Brandhorst, Daniel
AU - Bretzel, Reinhard G.
AU - Federlin, Konrad
AU - Goke, Burkhard
PY - 1995/8
Y1 - 1995/8
N2 - Glucagon-like peptide-I (GLP-I) is a potent incretin hormone that is now considered as a new therapeutic tool in the treatment of diabetes mellitus. In this study we characterized the effects of GLP-I on peptide hormone release from isolated human pancreatic islets. GLP-I stimulated insulin release in the presence of 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 166%; 10 mM glucose + 10 nM GLP-I, 222%) but had only a weak insulinotropic effect (128%) at 2.8 mM glucose. Glucagon release was inhibited by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 72%) and by 10 nM GLP-I at 2.8mM glucose (67%). Somatostatin secretion was increased by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 166%). GLP-I stimulated somatostatin release in the presence of 2.8 mM glucose (172%). Pancreatic polypeptide (PP) secretion was enhanced by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 236%). GLP-I induced PP release only in the presence of 2.8 mM glucose (184%).
AB - Glucagon-like peptide-I (GLP-I) is a potent incretin hormone that is now considered as a new therapeutic tool in the treatment of diabetes mellitus. In this study we characterized the effects of GLP-I on peptide hormone release from isolated human pancreatic islets. GLP-I stimulated insulin release in the presence of 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 166%; 10 mM glucose + 10 nM GLP-I, 222%) but had only a weak insulinotropic effect (128%) at 2.8 mM glucose. Glucagon release was inhibited by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 72%) and by 10 nM GLP-I at 2.8mM glucose (67%). Somatostatin secretion was increased by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 166%). GLP-I stimulated somatostatin release in the presence of 2.8 mM glucose (172%). Pancreatic polypeptide (PP) secretion was enhanced by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 236%). GLP-I induced PP release only in the presence of 2.8 mM glucose (184%).
KW - Glucagon
KW - Glucagon-like peptide-I (GLP-I)
KW - Hormone secretion
KW - Human pancreatic islets
KW - Insulin
KW - Somatostatin
UR - http://www.scopus.com/inward/record.url?scp=0029028687&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029028687&partnerID=8YFLogxK
U2 - 10.1097/00006676-199508000-00014
DO - 10.1097/00006676-199508000-00014
M3 - Article
C2 - 7479679
AN - SCOPUS:0029028687
SN - 0885-3177
VL - 11
SP - 196
EP - 200
JO - Pancreas
JF - Pancreas
IS - 2
ER -
