The effects of glucagon-like peptide-i (glp-i) on hormone secretion from isolated human pancreatic islets

Hans Christoph Fehmann, Bernd Josef Hering, Markus Joachim Wolf, Heide Brandhorst, Daniel Brandhorst, Reinhard G. Bretzel, Konrad Federlin, Burkhard Goke

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53 Scopus citations

Abstract

Glucagon-like peptide-I (GLP-I) is a potent incretin hormone that is now considered as a new therapeutic tool in the treatment of diabetes mellitus. In this study we characterized the effects of GLP-I on peptide hormone release from isolated human pancreatic islets. GLP-I stimulated insulin release in the presence of 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 166%; 10 mM glucose + 10 nM GLP-I, 222%) but had only a weak insulinotropic effect (128%) at 2.8 mM glucose. Glucagon release was inhibited by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 72%) and by 10 nM GLP-I at 2.8mM glucose (67%). Somatostatin secretion was increased by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 166%). GLP-I stimulated somatostatin release in the presence of 2.8 mM glucose (172%). Pancreatic polypeptide (PP) secretion was enhanced by 10 mM glucose (2.8 mM glucose, 100%; 10 mM glucose, 236%). GLP-I induced PP release only in the presence of 2.8 mM glucose (184%).

Original languageEnglish (US)
Pages (from-to)196-200
Number of pages5
JournalPancreas
Volume11
Issue number2
DOIs
StatePublished - Aug 1995

Keywords

  • Glucagon
  • Glucagon-like peptide-I (GLP-I)
  • Hormone secretion
  • Human pancreatic islets
  • Insulin
  • Somatostatin

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    Fehmann, H. C., Hering, B. J., Wolf, M. J., Brandhorst, H., Brandhorst, D., Bretzel, R. G., Federlin, K., & Goke, B. (1995). The effects of glucagon-like peptide-i (glp-i) on hormone secretion from isolated human pancreatic islets. Pancreas, 11(2), 196-200. https://doi.org/10.1097/00006676-199508000-00014