TY - JOUR
T1 - The effects of enhanced external counterpulsation on time- and frequency-domain measures of heart rate variability
AU - Michaels, Andrew D.
AU - Bart, Bradley A.
AU - Pinto, Thomas
AU - Lafferty, James
AU - Fung, Gordon
AU - Kennard, Elizabeth D.
N1 - Funding Information:
This study was sponsored by Vasomedical, Inc, Westbury, NY.
PY - 2007/11
Y1 - 2007/11
N2 - Background and Purpose: We hypothesized that symptom improvement from enhanced external counterpulsation (EECP) is related to improved heart rate variability (HRV). Methods: This prospective, multicenter study enrolled 27 patients with angina who underwent 48-hour ambulatory electrocardiogram monitoring at baseline, immediately after 35 hours of EECP, and at 1 month. Primary end points included change in time-domain (SD of normal-to-normal intervals) and frequency-domain HRV. Results: Twenty-four patients completed the full course of EECP therapy and 3 ambulatory electrocardiograms. There were no significant changes in time-domain HRV measures after EECP. Patients younger than 65 years and those with heart failure had improved SD of normal-to-normal interval after EECP (P = .02). Although frequency-domain HRV measures did not change in the overall cohort, patients with diabetes had improved daytime low-frequency power (P = .016). Conclusions: There was no significant change in the time- or frequency-domain HRV measures after EECP. In diabetic individuals, there was an increase in low-frequency HRV, which has been associated with reduced mortality.
AB - Background and Purpose: We hypothesized that symptom improvement from enhanced external counterpulsation (EECP) is related to improved heart rate variability (HRV). Methods: This prospective, multicenter study enrolled 27 patients with angina who underwent 48-hour ambulatory electrocardiogram monitoring at baseline, immediately after 35 hours of EECP, and at 1 month. Primary end points included change in time-domain (SD of normal-to-normal intervals) and frequency-domain HRV. Results: Twenty-four patients completed the full course of EECP therapy and 3 ambulatory electrocardiograms. There were no significant changes in time-domain HRV measures after EECP. Patients younger than 65 years and those with heart failure had improved SD of normal-to-normal interval after EECP (P = .02). Although frequency-domain HRV measures did not change in the overall cohort, patients with diabetes had improved daytime low-frequency power (P = .016). Conclusions: There was no significant change in the time- or frequency-domain HRV measures after EECP. In diabetic individuals, there was an increase in low-frequency HRV, which has been associated with reduced mortality.
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U2 - 10.1016/j.jelectrocard.2007.04.002
DO - 10.1016/j.jelectrocard.2007.04.002
M3 - Article
C2 - 17532337
AN - SCOPUS:35748978517
SN - 0022-0736
VL - 40
SP - 515
EP - 521
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
IS - 6
ER -
