The Effects of Depressed Environmental Oxygen Tensions on Periosteal Proliferation of Mouse Femurs

Arlen R. Severson, Edgar A. Tonna

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Mice subjected to femoral trauma in order to induce periosteal proliferation were exposed to atmospheres of either air, 15% O2 or 10% O2. TDR-3H autoradiographs revealed that 15% ambient O2 concentrations did not markedly affect the periosteal response. Ambient gas concentrations of 10% O2 reduced the labeling index of intact and traumatized femurs only slightly. The decreased ambient concentrations of O2 do not appear to affect the trauma site sufficiently to enhance a local tissue factor capable of stimulating cell proliferation.

Original languageEnglish (US)
Pages (from-to)315-319
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume129
Issue number1
DOIs
StatePublished - Oct 1968

Bibliographical note

Funding Information:
Research supported by NIH Grants 2-F2-AM-30,972 and 1-RO1-HDO3677-01, and by the U. S. Atomic Energy Commission. 10 1968 129 1 315 319

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