The effect on bone growth enhancement of implant coatings with hydroxyapatite and collagen deposited electrochemically and by plasma spray

Henrik Daugaard, Brian Elmengaard, Joan E. Bechtold, Thomas Jensen, Kjeld Soballe

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Skeletal bone consists of hydroxyapatite (HA) [Ca10(PO 4)6(OH)2] and collagen type I, both of which are osseoconductive. The goal of osseointegration of orthopedic and dental implants is the rapid achievement of a mechanically stable long-lasting fixation between bone and an implant surface. In this study, we evaluated the mechanical fixation and tissue distribution surrounding implants coated with three surfaces: plasma-sprayed HA coating, thinner coating of electrochemical-assisted deposition of HA, and an identical thin coating with a top layer of mineralized collagen. Uncoated plasma-sprayed titanium (Ti-6Al-4V) served as negative control. The electrochemical-assisted deposition was performed near physiological conditions. We used a canine experimental joint replacement model with four cylindrical implants (one of each treatment group) inserted in the humeri cancellous metaphyseal bone in a 1 mm gap. Observation time was 4 weeks. The mechanical fixation was quantified by pushout test to failure, and the peri-implant tissue formation by histomorphometric evaluation. HA coatings deposited by plasma spray technique or electrochemically, increased the mechanical fixation and bone ongrowth, but there was no statistical difference between the individual HA applications. Addition of collagen to the mineralized phase of the coating to create a more bone natural surface did not improve the osseoconductive effect of HA.

Original languageEnglish (US)
Pages (from-to)913-921
Number of pages9
JournalJournal of Biomedical Materials Research - Part A
Volume92
Issue number3
DOIs
StatePublished - Mar 1 2010

Keywords

  • Electrochemistry
  • Hydroxyapatite
  • Implants
  • Materials testing
  • Osseointegration

Fingerprint Dive into the research topics of 'The effect on bone growth enhancement of implant coatings with hydroxyapatite and collagen deposited electrochemically and by plasma spray'. Together they form a unique fingerprint.

  • Cite this