The effect of vagotomy on the satiety effects of neuropeptides and naloxone

John E. Morley, Allen S. Levine, Julie Kneip, Martha Grace

Research output: Contribution to journalArticlepeer-review

103 Scopus citations

Abstract

As abdominal vagotomy blocks the satiety effect of cholecystokinin-octapeptide, we felt it would be worthwhile to examine whether the satiety effect of any of the other putative satiety neuropeptides was mediated through the vagus. We confirmed that the satiety effect of peripherally administered cholecystokinin (10 μg/kg) was mediated through the vagus. In addition, the satiety effect of peripherally administered TRH (8 mg/kg) also was not present in vagotomized animals. Vagotomy had no effect on the satiety effects of peripherally administered bombesin, calcitonin and naloxone. Nor did vagotomy alter the satiety effect produced by central administration of bombesin, TRH, calcitonin nor naloxone.

Original languageEnglish (US)
Pages (from-to)1943-1947
Number of pages5
JournalLife Sciences
Volume30
Issue number22
DOIs
StatePublished - May 31 1982

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