The effect of the opioid-benzodiazepine, tifluadom, on ingestive behaviors

John E. Morley, Allen S. Levine, Martha Grace, Julie Kneip, H. Zeugner

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A large body of evidence has suggested a role for the endogenous opiates and their receptors in the regulation of appetite. In this study, we report on the effects of tifluadom, a noval opiate with a benzodiazepine-like structure and preferential activity at the K opiate receptor, on ingestive behaviors. Tifluadom increases food intake in rats without altering water intake. Tifluadom's effect on feeding is more potent than that of morphine or ketocyclazocine and equivalent to that of butorphanol. The effect is partially resistant to naloxone antagonism. Tifluadom is more potent when administered subcutaneously than when given intraperitoneally. These data provide further support for the concept that K opiate receptors represent an important component of the natural feeding drive.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalEuropean Journal of Pharmacology
Volume93
Issue number3-4
DOIs
StatePublished - Sep 30 1983

Keywords

  • Appetite
  • Benzodiazepine
  • Butorphanol
  • K Receptor
  • Morphine
  • Naloxone
  • Opiate receptors
  • Tifluadom

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