The effect of subconjunctival hep-ii peptide on glaucoma filtration surgery in rabbits

S. Murali, Y. J. Choi, W. F. Obritsch, E. A. Mindrup, Amy P Skubitz, Martha M Wright

Research output: Contribution to journalArticle

Abstract

Purpose. We studied the effect of Hep-II, a synthetic peptide derived from type IV collagen, on filtration surgery in rabbits. Methods. Twelve New Zealand White rabbits underwent glaucoma filtration surgery in the right eye. Six of the rabbits received sub-conjunctival injection of one milligram of Hep-II dissolved in O.I milliliters of distilled water immediately following filtration surgery and on every other day for a total of eight injections. The six control rabbits received an equivalent amount of distilled water on the same days, The intraocular pressure was evaluated post operatively every day through day 13 and then every other day through day 27 followed by every fourth day until day 35. Resultg. The intraocular pressure in the rabbits treated with the Hep-II peptide were lower than the control rabbits on all the days. A statistically significant difference was observed on post-operative days 7 , 9, 25, 27, 31, and 35. Conclusions. Hep-II is effective in prolonging the effect of glaucoma filtration surgery in rabbits and may be an alternative to other anti-fibrolic agents.

Original languageEnglish (US)
JournalInvestigative Ophthalmology and Visual Science
Volume38
Issue number4
StatePublished - Dec 1 1997

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Filtering Surgery
Glaucoma
Rabbits
Peptides
Intraocular Pressure
Injections
Collagen Type IV
Water

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The effect of subconjunctival hep-ii peptide on glaucoma filtration surgery in rabbits. / Murali, S.; Choi, Y. J.; Obritsch, W. F.; Mindrup, E. A.; Skubitz, Amy P; Wright, Martha M.

In: Investigative Ophthalmology and Visual Science, Vol. 38, No. 4, 01.12.1997.

Research output: Contribution to journalArticle

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AU - Choi, Y. J.

AU - Obritsch, W. F.

AU - Mindrup, E. A.

AU - Skubitz, Amy P

AU - Wright, Martha M

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AB - Purpose. We studied the effect of Hep-II, a synthetic peptide derived from type IV collagen, on filtration surgery in rabbits. Methods. Twelve New Zealand White rabbits underwent glaucoma filtration surgery in the right eye. Six of the rabbits received sub-conjunctival injection of one milligram of Hep-II dissolved in O.I milliliters of distilled water immediately following filtration surgery and on every other day for a total of eight injections. The six control rabbits received an equivalent amount of distilled water on the same days, The intraocular pressure was evaluated post operatively every day through day 13 and then every other day through day 27 followed by every fourth day until day 35. Resultg. The intraocular pressure in the rabbits treated with the Hep-II peptide were lower than the control rabbits on all the days. A statistically significant difference was observed on post-operative days 7 , 9, 25, 27, 31, and 35. Conclusions. Hep-II is effective in prolonging the effect of glaucoma filtration surgery in rabbits and may be an alternative to other anti-fibrolic agents.

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