The effect of prostaglandins (PGE2 and PGF) on food intake in rats

Allen S. Levine, John E. Morley

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51 Scopus citations


Intracerebroventricular administration of PGF and PGE2 suppressed food intake in several feeding models. PGF (20 μg) and PGE2 (20 μg to 1 μg) suppressed food intake following a 24 hour starvation. PGF (20 μg) and PGE2 (20 μg) suppressed food intake following central administration of the feeding induces norepinephrine and muscimol. These prostaglandins also suppressed stress induced eating using the tail pinch model at doses of 20 μg, 10 μg and 5 μg with eating returning to control levels at the 1 μg dose. D-Ala Methionine Enkephalin failed to alter the suppressive effects of PGF and PGE2 at a dose of 1 μg but successfully reversed the effect of PGF at a 10 μg dose while still having no effect on PGE2 suppression of feeding.

Original languageEnglish (US)
Pages (from-to)735-738
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Issue number5
StatePublished - Nov 1981


  • Food intake
  • Prostaglandins
  • Stress induced eating
  • Tail pinch


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