The effect of preceding context on inhibition: An event-related fMRI study

S. Durston, K. M. Thomas, M. S. Worden, Y. Yang, B. J. Casey

Research output: Contribution to journalArticle

247 Scopus citations

Abstract

In this study we combined event-related fMRI with a parametric manipulation of the go nogo paradigm to examine the effect of preceding context on inhibitory processes. Nogo trials were preceded by either 1, 3, or 5 go trials and then compared to one another. Two distinct patterns of activation were associated with behavioral inhibition: First, the ventral prefrontal cortex, cingulate gyrus, and superior parietal regions showed a context effect with an increase in MR signal to nogo trials with increasing number of preceding go trials. Second, anterior regions in the supplementary and premotor cortex showed an increase in MR signal on the nogo condition after 5 preceding go trials, but not after only 1 or 3. A model using the BOLD response in our data was used to verify that the effect of context was not an artifact of the randomization scheme used in the design.

Original languageEnglish (US)
Article number91074
Pages (from-to)449-453
Number of pages5
JournalNeuroImage
Volume16
Issue number2
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

Keywords

  • Context
  • Event-related
  • Functional MRI
  • Inhibition

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