Abstract
The non-selective opioid receptor antagonist naloxone decreases the robust feeding observed after i.c.v. injection of neuropeptide Y (NPY). In the present study we evaluated the effects of three selective opioid receptor antagonists on NPY-induced feeding. Graded doses of norbinaltorphimine (norBNI), β-funaltrexamine (β-FNA) and naltrindole (NTI), antagonists of the kappa, mu and delta receptors respectively, were preinjected (i.c.v.) in male rats prior to injection of 5 μg NPY (i.c.v.). Food intake was measured 1, 2 and 4 h post-NPY injection. Injection of β-FNA and norBNI were most effective in reducing NPY-induced feeding, whereas NTI had little effect on NPY-induced feeding.
Original language | English (US) |
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Pages (from-to) | 325-328 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 631 |
Issue number | 2 |
DOIs | |
State | Published - Dec 24 1993 |
Keywords
- Feeding
- Naltrindole (NTI)
- Neuropeptide Y (NPY)
- Norbinaltorphimine (norBNI)
- Opioid
- β-Funaltrexamine (β-FNA)