The effect of norbinaltorphimine, β-funaltrexamine and naltrindole on NPY-induced feeding

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Abstract

The non-selective opioid receptor antagonist naloxone decreases the robust feeding observed after i.c.v. injection of neuropeptide Y (NPY). In the present study we evaluated the effects of three selective opioid receptor antagonists on NPY-induced feeding. Graded doses of norbinaltorphimine (norBNI), β-funaltrexamine (β-FNA) and naltrindole (NTI), antagonists of the kappa, mu and delta receptors respectively, were preinjected (i.c.v.) in male rats prior to injection of 5 μg NPY (i.c.v.). Food intake was measured 1, 2 and 4 h post-NPY injection. Injection of β-FNA and norBNI were most effective in reducing NPY-induced feeding, whereas NTI had little effect on NPY-induced feeding.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalBrain Research
Volume631
Issue number2
DOIs
StatePublished - Dec 24 1993

Keywords

  • Feeding
  • Naltrindole (NTI)
  • Neuropeptide Y (NPY)
  • Norbinaltorphimine (norBNI)
  • Opioid
  • β-Funaltrexamine (β-FNA)

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