The effect of iron on mammalian cortical neurons in culture

Kenneth F Swaiman; Valynda L. Machen

doi:10.1007/BF00964844

The effect of iron on mammalian cortical neurons in culture

Kenneth F Swaiman, Valynda L. Machen

Neurology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We added iron in the ferric form to predominantly neuronal, cortical cell cultures, and determined clonazepam-displaceable [³H]diazepam binding, choline acetyltransferase activity, high-affinity [³H]GABA uptake, and glutamic acid decarboxylase activity. Chronic exposure (14 days) to low concentrations (0.01, 0.04, and 0.1 μg/ml) of added ferric iron resulted in a significant decrease in each of the measures studied.

Original language	English (US)
Pages (from-to)	1261-1268
Number of pages	8
Journal	Neurochemical Research
Volume	10
Issue number	9
DOIs	https://doi.org/10.1007/BF00964844
State	Published - Sep 1985

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title = "The effect of iron on mammalian cortical neurons in culture",

abstract = "We added iron in the ferric form to predominantly neuronal, cortical cell cultures, and determined clonazepam-displaceable [3H]diazepam binding, choline acetyltransferase activity, high-affinity [3H]GABA uptake, and glutamic acid decarboxylase activity. Chronic exposure (14 days) to low concentrations (0.01, 0.04, and 0.1 μg/ml) of added ferric iron resulted in a significant decrease in each of the measures studied.",

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T1 - The effect of iron on mammalian cortical neurons in culture

AU - Swaiman, Kenneth F

AU - Machen, Valynda L.

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N2 - We added iron in the ferric form to predominantly neuronal, cortical cell cultures, and determined clonazepam-displaceable [3H]diazepam binding, choline acetyltransferase activity, high-affinity [3H]GABA uptake, and glutamic acid decarboxylase activity. Chronic exposure (14 days) to low concentrations (0.01, 0.04, and 0.1 μg/ml) of added ferric iron resulted in a significant decrease in each of the measures studied.

AB - We added iron in the ferric form to predominantly neuronal, cortical cell cultures, and determined clonazepam-displaceable [3H]diazepam binding, choline acetyltransferase activity, high-affinity [3H]GABA uptake, and glutamic acid decarboxylase activity. Chronic exposure (14 days) to low concentrations (0.01, 0.04, and 0.1 μg/ml) of added ferric iron resulted in a significant decrease in each of the measures studied.

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ER -

The effect of iron on mammalian cortical neurons in culture

Abstract

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