The effect of iron on mammalian cortical neurons in culture

Kenneth F Swaiman, Valynda L. Machen

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We added iron in the ferric form to predominantly neuronal, cortical cell cultures, and determined clonazepam-displaceable [3H]diazepam binding, choline acetyltransferase activity, high-affinity [3H]GABA uptake, and glutamic acid decarboxylase activity. Chronic exposure (14 days) to low concentrations (0.01, 0.04, and 0.1 μg/ml) of added ferric iron resulted in a significant decrease in each of the measures studied.

Original languageEnglish (US)
Pages (from-to)1261-1268
Number of pages8
JournalNeurochemical Research
Volume10
Issue number9
DOIs
StatePublished - Sep 1 1985

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