The effect of ileal bypass on atherosclerosis and hypercholesterolemia in the rabbit

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Abstract

White New Zealand rabbits were divided into four groups: Group I (controls) fed standard rabbit pellets for 4 months; Group II fed a 2 percent cholesterol diet for 4 months; Group III fed a 2 percent cholesterol diet for 4 months subsequent to ileal bypass surgery; and Group IV subjected to ileal bypass after 4 months on the 2 percent cholesterol diet and then continued on the diet and followed for periods up to 15 months. Group I rabbits exhibited no hypercholesterolemia or atherosclerosis. Group II animals had an average blood cholesterol level of 1,265 mg. percent and were severely atherosclerotic, as shown by a 50 percent myocardial infarction rate. Group III rabbits retained cholesterol values below that of the controls and showed no evidence of atherosclerosis. Group IV animals, if permitted to survive 6 months or longer subsequent to a fall in cholesterol levels below 100 mg. percent, showed no progression of acute atherosclerosis, but evidenced regression of liver, spleen, and kidney foam cell and cholesterol accumulations; and fibrosis of established intimal plaques, with a total aorta cholesterol content per residue weight 33.8 percent lower than that of Group II, and possibly fewer plaques than at the height of their atherosclerosis.

Original languageEnglish (US)
Pages (from-to)22-36
Number of pages15
JournalSurgery
Volume58
Issue number1
StatePublished - Jul 1 1965

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