Abstract
(1) Posterior hypothalamic stimulation causes a 36% reduction in colonic perfusion in the puppy with a simultaneous rise in vascular resistance. Neither effect is seen in the presence of hypoxia. (2) Hypoxia alone produces a 17% increase in colonic perfusion with a 33% decrease in resistance. In the presence of PHS, hypoxia is associated with an 83% increase in perfusion and a 43% reduction in resistance. (3) The data suggest that sympathetic overactivity may play a role in the genesis of the ischemic lesion of neonatal necrotizing enterocolitis, while hypoxia may be operative in the development of the hemorrhagic lesions. This concept is discussed in relation to other hypotheses regarding the genesis of this disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 747-756 |
| Number of pages | 10 |
| Journal | Journal of Pediatric Surgery |
| Volume | 8 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 1973 |
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The effect of hypoxia and posterior hypothalamic stimulation on colonic blood flow in the weanling puppy. / Broadie, Thomas A.; Devedas, Mohandas; Rysavy, Joseph; Delaney, John P; Leonard, Arnold S.
In: Journal of Pediatric Surgery, Vol. 8, No. 5, 01.01.1973, p. 747-756.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of hypoxia and posterior hypothalamic stimulation on colonic blood flow in the weanling puppy
AU - Broadie, Thomas A.
AU - Devedas, Mohandas
AU - Rysavy, Joseph
AU - Delaney, John P
AU - Leonard, Arnold S.
PY - 1973/1/1
Y1 - 1973/1/1
N2 - (1) Posterior hypothalamic stimulation causes a 36% reduction in colonic perfusion in the puppy with a simultaneous rise in vascular resistance. Neither effect is seen in the presence of hypoxia. (2) Hypoxia alone produces a 17% increase in colonic perfusion with a 33% decrease in resistance. In the presence of PHS, hypoxia is associated with an 83% increase in perfusion and a 43% reduction in resistance. (3) The data suggest that sympathetic overactivity may play a role in the genesis of the ischemic lesion of neonatal necrotizing enterocolitis, while hypoxia may be operative in the development of the hemorrhagic lesions. This concept is discussed in relation to other hypotheses regarding the genesis of this disease.
AB - (1) Posterior hypothalamic stimulation causes a 36% reduction in colonic perfusion in the puppy with a simultaneous rise in vascular resistance. Neither effect is seen in the presence of hypoxia. (2) Hypoxia alone produces a 17% increase in colonic perfusion with a 33% decrease in resistance. In the presence of PHS, hypoxia is associated with an 83% increase in perfusion and a 43% reduction in resistance. (3) The data suggest that sympathetic overactivity may play a role in the genesis of the ischemic lesion of neonatal necrotizing enterocolitis, while hypoxia may be operative in the development of the hemorrhagic lesions. This concept is discussed in relation to other hypotheses regarding the genesis of this disease.
UR - http://www.scopus.com/inward/record.url?scp=0015805801&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015805801&partnerID=8YFLogxK
U2 - 10.1016/0022-3468(73)90417-X
DO - 10.1016/0022-3468(73)90417-X
M3 - Article
VL - 8
SP - 747
EP - 756
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
SN - 0022-3468
IS - 5
ER -