The effect of hypoxia and posterior hypothalamic stimulation on colonic blood flow in the weanling puppy

Thomas A. Broadie, Mohandas Devedas, Joseph Rysavy, John P. Delaney, Arnold S. Leonard

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

(1) Posterior hypothalamic stimulation causes a 36% reduction in colonic perfusion in the puppy with a simultaneous rise in vascular resistance. Neither effect is seen in the presence of hypoxia. (2) Hypoxia alone produces a 17% increase in colonic perfusion with a 33% decrease in resistance. In the presence of PHS, hypoxia is associated with an 83% increase in perfusion and a 43% reduction in resistance. (3) The data suggest that sympathetic overactivity may play a role in the genesis of the ischemic lesion of neonatal necrotizing enterocolitis, while hypoxia may be operative in the development of the hemorrhagic lesions. This concept is discussed in relation to other hypotheses regarding the genesis of this disease.

Original languageEnglish (US)
Pages (from-to)747-756
Number of pages10
JournalJournal of Pediatric Surgery
Volume8
Issue number5
DOIs
StatePublished - Oct 1973

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