The effect of hemodialysis on neutrophil chemotactic responsiveness

William H. Greene, Casann Ray, Michael Mauer, Paul G. Quie

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Fifteen patients with chronic renal failure had depressed neutrophil chemotactic responsiveness following several hemodialysis treatments. The chemotactic index (C.I.) of these patients was 12.7 ± 6.4 as compared with 72.8 ± 22.7 for controls (p < 0.001). Patients with chronic renal failure, not on hemodialysis, had only mildly depressed neutrophil chemotactic responsiveness (42.3 ± 15; p < 0.01). Thus, hemodialysis impairs neutrophil function and may contribute to the increased risk of infection in uremic patients. Chemotactic responsiveness returned to normal in three patients following renal transplantation.

Original languageEnglish (US)
Pages (from-to)971-974
Number of pages4
JournalThe Journal of laboratory and clinical medicine
Volume88
Issue number6
StatePublished - Dec 1976

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