The Effect of Food-Deprivation on Lactic Dehydrogenase Activity in Immature Rat Brain

Kenneth F. Swaiman, Richard N. Wolfe

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


DNA concentration, weight, protein content, and LDH activity were studied in control and food-deprived rats at 7, 14, and 21 days. As in other studies, the DNA concentration, brain weight, and protein were decreased in the deprived animals. Total brain activity of LDH was less in the food-deprived animals. The LDH activity per cell increased with maturation and was essentially the same in both groups. Increasing total brain activity of LDH during maturation is due to both increased activity per cell and increased numbers of cells. Food deprivation in immature animals results in lowered total brain activity of LDH, primarily because of diminished cell multiplication. The LDH isozyme pattern of development was not affected by food-deprivation despite decreased total LDH activity.

Original languageEnglish (US)
Pages (from-to)185-187
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - May 1970

Bibliographical note

Funding Information:
This study was supported in part by a grant from the Graduate School of the University of Minnesota and USPHS Grant HD 01889.

Copyright 2016 Elsevier B.V., All rights reserved.


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