The effect of feedback on alternans formation in the heart

Stephen D. McIntyre, Yoichiro Mori, Elena G. Tolkacheva

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

A beat-to-beat alternation in the duration of the action potential (APD) of myocytes, i.e. alternans, is believed to be a direct precursor of ventricular fibrillation (VF) in the whole heart. A common technique for the prediction of alternans uses the restitution curve, the nonlinear functional relationship between the APD and the preceding diastolic interval (DI). It was proposed that alternans appears when the magnitude of the slope of the restitution curve exceeds one, known as the restitution hypothesis. However, this restitution hypothesis was derived in the presence of feedback, i.e. the partial dependence of the DI on the immediate preceding APD. Physiologically, the heart rate exhibits substantial variations, known as heart rate variability (HRV), which might affect the feedback relationship. In this manuscript, we aim to investigate the effect of feedback on alternans formation in the heart.

Original languageEnglish (US)
Title of host publicationASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012
Pages585-589
Number of pages5
DOIs
StatePublished - Dec 1 2012
EventASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012 - Fort Lauderdale, FL, United States
Duration: Oct 17 2012Oct 19 2012

Publication series

NameASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012
Volume1

Other

OtherASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012
CountryUnited States
CityFort Lauderdale, FL
Period10/17/1210/19/12

    Fingerprint

Cite this

McIntyre, S. D., Mori, Y., & Tolkacheva, E. G. (2012). The effect of feedback on alternans formation in the heart. In ASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012 (pp. 585-589). (ASME 2012 5th Annual Dynamic Systems and Control Conference Joint with the JSME 2012 11th Motion and Vibration Conference, DSCC 2012-MOVIC 2012; Vol. 1). https://doi.org/10.1115/DSCC2012-MOVIC2012-8646