Abstract
A study of the effect of ethacrynic acid on guinea-pig blood, cerebrospinal fluid and perilymph Na and K is reported. After exposure to 50 mg/kg of ethacrynic acid administered over 48 h, the perilymph K, 1.6 h following the last injection, was found to be markedly elevated above control values (0.01 > P > 0.001). This change in K may result from ethacrynic acid inhibition of a membrane ATPase system. One speculation is that ethacrynic acid ototoxicity results from the inhibition of cochlear-duct membrane ATPase.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 279-287 |
| Number of pages | 9 |
| Journal | ORL |
| Volume | 32 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1970 |
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