The effect of ethacrynic acid on perilymph NA and K (preliminary report)

Kent S. Wilson, S. K. Juhn

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A study of the effect of ethacrynic acid on guinea-pig blood, cerebrospinal fluid and perilymph Na and K is reported. After exposure to 50 mg/kg of ethacrynic acid administered over 48 h, the perilymph K, 1.6 h following the last injection, was found to be markedly elevated above control values (0.01 > P > 0.001). This change in K may result from ethacrynic acid inhibition of a membrane ATPase system. One speculation is that ethacrynic acid ototoxicity results from the inhibition of cochlear-duct membrane ATPase.

Original languageEnglish (US)
Pages (from-to)279-287
Number of pages9
Issue number5
StatePublished - 1970


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