The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea

Alan H B Wu; Jeffrey Tabas; Johnathan Stein; Mihael Potocki; Christian Mueller; James McCord; Mark Richards; Oliver Hartmann; Richard Nowak; W. Frank Peacock; Piotr Ponikowski; Martin Moeckel; Christopher Hogan; Gerasimos S. Filippatos; Salvatore Di Somma; Inder Anand; Leong Ng; Sean Xavier Neath; Robert Christenson; Nils G. Morgenthaler; Stefan D. Anker; Alan S. Maisel

doi:10.3109/1354750X.2012.687014

The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea

Alan H B Wu, Jeffrey Tabas, Johnathan Stein, Mihael Potocki, Christian Mueller, James McCord, Mark Richards, Oliver Hartmann, Richard Nowak, W. Frank Peacock, Piotr Ponikowski, Martin Moeckel, Christopher Hogan, Gerasimos S. Filippatos, Salvatore Di Somma, Inder Anand, Leong Ng, Sean Xavier Neath, Robert Christenson, Nils G. MorgenthalerStefan D. Anker, Alan S. Maisel

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Serum mid-regional pro-atrial natriuretic peptide (MR-proANP) and pro-adrenomedullin (MR-proADM) are novel biomarkers for acute heart failure (AHF). Like other AFH biomarkers, the performance of these tests are affected by the presence of clinical variables such as renal failure and obesity. In a substudy of the Biomarkers from Acute Heart Failure Study, we show that diabetes did not influence the performance of these markers with regards to AHF diagnosis or 90-day all cause death. However, in patients without AHF, increased MR-proADM alone was associated with the presence of diabetes.

Original language	English (US)
Pages (from-to)	490-497
Number of pages	8
Journal	Biomarkers
Volume	17
Issue number	6
DOIs	https://doi.org/10.3109/1354750X.2012.687014
State	Published - Sep 1 2012

Keywords

Heart failure
Mid-regional pro-adrenomedullin
Mid-regional pro-atrial natriuretic peptide
Risk stratification

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/1354750X.2012.687014

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Wu, A. H. B., Tabas, J., Stein, J., Potocki, M., Mueller, C., McCord, J., Richards, M., Hartmann, O., Nowak, R., Peacock, W. F., Ponikowski, P., Moeckel, M., Hogan, C., Filippatos, G. S., Di Somma, S., Anand, I., Ng, L., Neath, S. X., Christenson, R., ... Maisel, A. S. (2012). The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea. Biomarkers, 17(6), 490-497. https://doi.org/10.3109/1354750X.2012.687014

Wu, AHB, Tabas, J, Stein, J, Potocki, M, Mueller, C, McCord, J, Richards, M, Hartmann, O, Nowak, R, Peacock, WF, Ponikowski, P, Moeckel, M, Hogan, C, Filippatos, GS, Di Somma, S, Anand, I, Ng, L, Neath, SX, Christenson, R, Morgenthaler, NG, Anker, SD & Maisel, AS 2012, 'The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea', Biomarkers, vol. 17, no. 6, pp. 490-497. https://doi.org/10.3109/1354750X.2012.687014

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abstract = "Serum mid-regional pro-atrial natriuretic peptide (MR-proANP) and pro-adrenomedullin (MR-proADM) are novel biomarkers for acute heart failure (AHF). Like other AFH biomarkers, the performance of these tests are affected by the presence of clinical variables such as renal failure and obesity. In a substudy of the Biomarkers from Acute Heart Failure Study, we show that diabetes did not influence the performance of these markers with regards to AHF diagnosis or 90-day all cause death. However, in patients without AHF, increased MR-proADM alone was associated with the presence of diabetes.",

keywords = "Heart failure, Mid-regional pro-adrenomedullin, Mid-regional pro-atrial natriuretic peptide, Risk stratification",

author = "Wu, {Alan H B} and Jeffrey Tabas and Johnathan Stein and Mihael Potocki and Christian Mueller and James McCord and Mark Richards and Oliver Hartmann and Richard Nowak and Peacock, {W. Frank} and Piotr Ponikowski and Martin Moeckel and Christopher Hogan and Filippatos, {Gerasimos S.} and {Di Somma}, Salvatore and Inder Anand and Leong Ng and Neath, {Sean Xavier} and Robert Christenson and Morgenthaler, {Nils G.} and Anker, {Stefan D.} and Maisel, {Alan S.}",

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doi = "10.3109/1354750X.2012.687014",

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T1 - The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea

AU - Wu, Alan H B

AU - Tabas, Jeffrey

AU - Stein, Johnathan

AU - Potocki, Mihael

AU - Mueller, Christian

AU - McCord, James

AU - Richards, Mark

AU - Hartmann, Oliver

AU - Nowak, Richard

AU - Peacock, W. Frank

AU - Ponikowski, Piotr

AU - Moeckel, Martin

AU - Hogan, Christopher

AU - Filippatos, Gerasimos S.

AU - Di Somma, Salvatore

AU - Anand, Inder

AU - Ng, Leong

AU - Neath, Sean Xavier

AU - Christenson, Robert

AU - Morgenthaler, Nils G.

AU - Anker, Stefan D.

AU - Maisel, Alan S.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Serum mid-regional pro-atrial natriuretic peptide (MR-proANP) and pro-adrenomedullin (MR-proADM) are novel biomarkers for acute heart failure (AHF). Like other AFH biomarkers, the performance of these tests are affected by the presence of clinical variables such as renal failure and obesity. In a substudy of the Biomarkers from Acute Heart Failure Study, we show that diabetes did not influence the performance of these markers with regards to AHF diagnosis or 90-day all cause death. However, in patients without AHF, increased MR-proADM alone was associated with the presence of diabetes.

AB - Serum mid-regional pro-atrial natriuretic peptide (MR-proANP) and pro-adrenomedullin (MR-proADM) are novel biomarkers for acute heart failure (AHF). Like other AFH biomarkers, the performance of these tests are affected by the presence of clinical variables such as renal failure and obesity. In a substudy of the Biomarkers from Acute Heart Failure Study, we show that diabetes did not influence the performance of these markers with regards to AHF diagnosis or 90-day all cause death. However, in patients without AHF, increased MR-proADM alone was associated with the presence of diabetes.

KW - Heart failure

KW - Mid-regional pro-adrenomedullin

KW - Mid-regional pro-atrial natriuretic peptide

KW - Risk stratification

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The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea

Abstract

Keywords

UN SDGs

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