The effect of diabetes on the diagnostic and prognostic performance of mid-region pro-atrial natriuretic peptide and mid-region pro-adrenomedullin in patients with acute dyspnea

Alan H B Wu, Jeffrey Tabas, Johnathan Stein, Mihael Potocki, Christian Mueller, James McCord, Mark Richards, Oliver Hartmann, Richard Nowak, W. Frank Peacock, Piotr Ponikowski, Martin Moeckel, Christopher Hogan, Gerasimos S. Filippatos, Salvatore Di Somma, Inder Anand, Leong Ng, Sean Xavier Neath, Robert Christenson, Nils G. MorgenthalerStefan D. Anker, Alan S. Maisel

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Serum mid-regional pro-atrial natriuretic peptide (MR-proANP) and pro-adrenomedullin (MR-proADM) are novel biomarkers for acute heart failure (AHF). Like other AFH biomarkers, the performance of these tests are affected by the presence of clinical variables such as renal failure and obesity. In a substudy of the Biomarkers from Acute Heart Failure Study, we show that diabetes did not influence the performance of these markers with regards to AHF diagnosis or 90-day all cause death. However, in patients without AHF, increased MR-proADM alone was associated with the presence of diabetes.

Original languageEnglish (US)
Pages (from-to)490-497
Number of pages8
JournalBiomarkers
Volume17
Issue number6
DOIs
StatePublished - Sep 1 2012

Keywords

  • Heart failure
  • Mid-regional pro-adrenomedullin
  • Mid-regional pro-atrial natriuretic peptide
  • Risk stratification

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