The effect of cholecystokinin octapeptide and glucagon (1-29) on food intake of weanling rats

S. A. Wager-Srdar, A. S. Levine

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Cholecystokinin octapeptide (CCK-8) and glucagon (GLG) decrease food intake of a number of species. However, the responsiveness of rats to the food intake effects of these peptides may develop differentially due to sex, age and/or developmental state. Male and female weanling rats decreased early dark cycle food intake following the administration of 5 and 10 μg/kg CCK-8 and male rats were more responsive than female rats, p<0.05. GLG did not decrease early dark cycle food intake of either male or female weanling rats. Weanling male rats increased plasma glucose and insulin levels in response to GLG administration, p<0.05. Male rats were retested with GLG (250 and 500 μg/kg) at 6, 9 and 22 weeks of age. GLG did not decrease food intake of these rats until they reached 9 weeks of age and they were still responsive at 22 weeks of age, p<0.05.

Original languageEnglish (US)
Pages (from-to)747-751
Number of pages5
JournalPhysiology and Behavior
Volume45
Issue number4
DOIs
StatePublished - Apr 1989

Keywords

  • Age
  • Food intake
  • Plasma insulin
  • Sex

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