The effect of calcitonin on food intake in diabetic mice

J. E. Morley, Allen S Levine, D. M. Brown, B. S. Handwerger

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The characteristic hyperphagia of the genetically obese diabetic (C57B1/Ks-db+/db+) mouse (db/db) is thought to be due to a defect in the satiety circuitry with a secondary overproduction of a circulating satiety factor to which they are insensitive. Recent studies have suggested that calcitonin may be a potent hormonal mediator of the satiety reflex. In this study it was shown that db/db mice were eight fold more sensitive to calcitonin than their heterozygote littermate controls. Mice with streptozotocin-induced diabetes were ten-fold more sensitive to calcitonin than their littermate controls. These results show that diabetes increases the sensitivity to the satiety effects of calcitonin.

Original languageEnglish (US)
Pages (from-to)17-20
Number of pages4
JournalPeptides
Volume3
Issue number1
DOIs
StatePublished - Jan 1 1982

Keywords

  • Appetite
  • Calcitonin
  • Diabetes
  • db/db Mice

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