The effect of calcitonin gene-related peptide on food intake involves aversive mechanisms

D. D. Krahn, B. A. Gosnell, A. S. Levine, J. E. Morley

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Calcitonin gene-related peptide (CGRP), the product of the calcitonin gene produced primarily in the central nervous system, has been shown to decrease food intake when administered intracerebroventricularly (ICV). Testing of CGRP (ICV) in both single bottle conditioned-aversion and differential starvation paradigms was done. In both paradigms, result using CGRP were consistent with those predicted for aversive agents. Therefore, CGRP apparently decreases feeding via aversive mechanisms.

Original languageEnglish (US)
Pages (from-to)5-7
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume24
Issue number1
DOIs
StatePublished - Jan 1986

Keywords

  • Aversion
  • Calcitonin gene-related peptide
  • Feeding
  • Satiety

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