Abstract
In this study we sought to determine whether exposure to the anesthetics diethyl ether and isoflurane influences the activity of hepatic cytochrome P450 2E1 and P450 reductases in the rat. Rats were fed a purified diet for 6 wk before anesthesia with 1 of 3 anesthetics: carbon dioxide, diethyl ether, or isoflurane. Cytochrome P450 2E1 and P450 reductases were measured in liver microsomes. No significant differences in enzyme activities were found among the groups. These results indicate that diethyl ether and isoflurane can be used to kill rats without inducing P450 enzymes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1063-1064 |
| Number of pages | 2 |
| Journal | Anesthesia and analgesia |
| Volume | 101 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 2005 |
Bibliographical note
Funding Information:Supported, in part, by the Sotatec Fund, and the Minnesota Agricultural Experimental Station
Copyright:
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