The effect of alcohol on serum high density lipoprotein (HDL). A Controlled Experiment

Gary E. Fraser, Joseph T. Anderson, Nedra Foster, Ronald Goldberg, David Jacobs, Henry Blackburn

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


A cross-over study using 11 male subjects and a closely controlled diet, investigated the effect of alcohol on serum high density lipoprotein (HDL) components. Smoking status and body weight remained essentially constant and exercise changes were adjusted for in the analysis. As compared to sucrose, alcohol consumption was associated with a significant elevation in serum apolipoprotein A-I (0.37 mg/dl/g/day of alcohol) with similar effects for serum HDL cholesterol (0.14 mg/dl/g/day of alcohol) and serum apolipoprotein A-II (0.11 mg/dl/g/day of alcohol) achieving borderline levels of statistical significance.

Original languageEnglish (US)
Pages (from-to)275-286
Number of pages12
Issue number3
StatePublished - Mar 1983

Bibliographical note

Funding Information:
This study was funded by a Genera1 Research Grant, University of Minnesota, also Grant SCOR Atherosclerosis (University of Chicago) HL-06481. * Present address: Department of Biostatistics and Epidemiology, Loma Linda University, Loma Linda, CA 92350, U.S.A. ** Present address: Division of Endocrinology and Metabolism, Department of Medicine, University of Miami, Miami, FL 33101, U.S.A.


  • Alcohol
  • Apolipoproteins
  • Cholesterol
  • Exercise
  • Serum high density lipoprotein


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