The effect of 16β-substitution on the structure and activity of digitoxigenin: Is there an additional binding interaction with Na⁺, K⁺-ATPase?

Keyphrases

• Na+-K+ ATPase 100%
• Binding Interaction 100%
• Digitoxigenin 100%
• Esters 80%
• Lactone Ring 60%
• Carbonyl 40%
• Inhibitory Activity 40%
• Hydroxyl 40%
• Decreased Activity 40%
• Increased Activity 20%
• Receptor-binding Domain 20%
• Formate 20%
• Carbon-14 20%
• Preferred Conformation 20%
• D-ring 20%
• Ring Conformation 20%
• Active Conformation 20%
• Intramolecular Hydrogen Bond 20%
• Oxygen Position 20%
• Ester Compounds 20%
• Active Positions 20%
• Hydrogen Bonds (H-bonds) 20%

Biochemistry, Genetics and Molecular Biology

• ATPase 100%
• Digitoxigenin 100%
• Conformation 80%
• Crystal Structure 20%
• Hydrogen Bond 20%
• Binding Site 20%
• Receptor Binding 20%