The E. Donnall Thomas lecture: Manipulating and visualizing T-cell alloresponses

Bruce R. Blazar

doi:10.1016/j.bbmt.2005.07.004

The E. Donnall Thomas lecture: Manipulating and visualizing T-cell alloresponses

Bruce R. Blazar

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

In summary, blockade of the costimulatory CD28/B7 pathway inhibits, but does not eliminate GVHD. Blockade of the coinhibitory CTLA4/B7 pathway accelerates GVHD. The incomplete efficacy of blocking the CD28/B7 pathway suggested that other pathways may be contributing to the generation of a productive immune response culminating in GVHD lethality.

Original language	English (US)
Pages (from-to)	651-656
Number of pages	6
Journal	Biology of Blood and Marrow Transplantation
Volume	11
Issue number	9
DOIs	https://doi.org/10.1016/j.bbmt.2005.07.004
State	Published - Sep 2005

Keywords

Alloengraftment
Alloresponses
Graft-versus-host disease
Imaging T-cell tracking

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbmt.2005.07.004

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title = "The E. Donnall Thomas lecture: Manipulating and visualizing T-cell alloresponses",

abstract = "In summary, blockade of the costimulatory CD28/B7 pathway inhibits, but does not eliminate GVHD. Blockade of the coinhibitory CTLA4/B7 pathway accelerates GVHD. The incomplete efficacy of blocking the CD28/B7 pathway suggested that other pathways may be contributing to the generation of a productive immune response culminating in GVHD lethality.",

keywords = "Alloengraftment, Alloresponses, Graft-versus-host disease, Imaging T-cell tracking",

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AB - In summary, blockade of the costimulatory CD28/B7 pathway inhibits, but does not eliminate GVHD. Blockade of the coinhibitory CTLA4/B7 pathway accelerates GVHD. The incomplete efficacy of blocking the CD28/B7 pathway suggested that other pathways may be contributing to the generation of a productive immune response culminating in GVHD lethality.

KW - Alloengraftment

KW - Alloresponses

KW - Graft-versus-host disease

KW - Imaging T-cell tracking

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The E. Donnall Thomas lecture: Manipulating and visualizing T-cell alloresponses

Abstract

Keywords

UN SDGs

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