The E. Donnall Thomas lecture: Manipulating and visualizing T-cell alloresponses

Research output: Contribution to journalReview articlepeer-review

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Abstract

In summary, blockade of the costimulatory CD28/B7 pathway inhibits, but does not eliminate GVHD. Blockade of the coinhibitory CTLA4/B7 pathway accelerates GVHD. The incomplete efficacy of blocking the CD28/B7 pathway suggested that other pathways may be contributing to the generation of a productive immune response culminating in GVHD lethality.

Original languageEnglish (US)
Pages (from-to)651-656
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume11
Issue number9
DOIs
StatePublished - Sep 2005

Keywords

  • Alloengraftment
  • Alloresponses
  • Graft-versus-host disease
  • Imaging T-cell tracking

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