The Dynamic Fungal Genome: Polyploidy, Aneuploidy and Copy Number Variation in Response to Stress

Pétra Vande Zande, Xin Zhou, Anna Selmecki

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Fungal species have dynamic genomes and often exhibit genomic plasticity in response to stress. This genome plasticity often comes with phenotypic consequences that affect fitness and resistance to stress. Fungal pathogens exhibit genome plasticity in both clinical and agricultural settings and often during adaptation to antifungal drugs, posing significant challenges to human health. Therefore, it is important to understand the rates, mechanisms, and impact of large genomic changes. This review addresses the prevalence of polyploidy, aneuploidy, and copy number variation across diverse fungal species, with special attention to prominent fungal pathogens and model species. We also explore the relationship between environmental stress and rates of genomic changes and highlight the mechanisms underlying genotypic and phenotypic changes. A comprehensive understanding of these dynamic fungal genomes is needed to identify novel solutions for the increase in antifungal drug resistance.

Original languageEnglish (US)
Pages (from-to)341-361
Number of pages21
JournalAnnual Review of Microbiology
StatePublished - Sep 15 2023

Bibliographical note

Publisher Copyright:
© 2023 Annual Reviews Inc.. All rights reserved.


  • adaptation to stress
  • aneuploidy
  • copy number variation
  • genome plasticity
  • polyploidy

PubMed: MeSH publication types

  • Journal Article
  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't


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