The dose-response effect of insulin sensitivity on albuminuria in children according to diabetes type

SEARCH for Diabetes in Youth Study

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: Insulin resistance is associated with microalbuminuria among youth with diabetes mellitus. We sought to determine the dose-response effect of insulin sensitivity (IS) on the magnitude of albuminuria and whether there is a threshold below which urine albumin excretion increases. Methods: These analyses included participants from the SEARCH for Diabetes in Youth Study with incident diabetes who completed a baseline study visit (n=2988).We estimated IS using a validated equation incorporating waist circumference, HbA1C, and fasting serum triglycerides. Multivariate regression analyses were performed to assess the effect of IS on urine albumin creatinine ratio (UACR), stratified by diabetes type. The IS threshold was then determined using segmented regressions within each diabetes type and incorporated into the multivariate model. Results: There was an association between IS and UACR in type 2 diabetes only (beta = -0.39; p < 0.001). There was strong statistical evidence for a threshold effect of IS score on UACR in the group of youth with type 2 (beta = 0.40; p <0.001) but not type 1 diabetes (p=0.3). Conclusions: In cross-sectional analyses, there is a negative association between IS and UACR in youth with type 2 but not type 1 diabetes, and this association likely includes a threshold effect of IS on UACR.

Original languageEnglish (US)
Pages (from-to)933-940
Number of pages8
JournalPediatric Nephrology
Volume31
Issue number6
DOIs
StatePublished - Jan 11 2016

Keywords

  • Insulin resistance
  • Metabolic syndrome
  • Microalbuminuria
  • Nephropathy
  • Urine:albumin creatinine ratio

Fingerprint Dive into the research topics of 'The dose-response effect of insulin sensitivity on albuminuria in children according to diabetes type'. Together they form a unique fingerprint.

  • Cite this