The donor kidney biopsy and its implications in predicting graft outcomes: A systematic review

C. J. Wang, J. B. Wetmore, G. S. Crary, B. L. Kasiske

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Despite a growing organ shortage in the United States, many deceased donor kidneys removed for transplantation are discarded. Kidney biopsy findings often play a role in these discards, although it is not clear whether biopsies reliably inform acceptance decisions. Therefore, we carried out a systematic review of the medical literature on the utility of both procurement and implantation biopsies for predicting posttransplant outcomes. Between January 1, 1994 and July 1, 2014, 47 studies were published in the English language literature that examined the association between pretransplant donor biopsy findings from 50 or more donors (with more than half being from deceased donors) and either posttransplant graft failure, delayed graft function, or graft function. In general, study quality was poor. All were retrospective or did not indicate if they were prospective. Results were heterogeneous, with authors as often as not concluding that biopsy results did not predict posttransplant outcomes. The percent glomerular sclerosis was most often examined, and failed to predict graft failure in 7 of 14 studies. Of 15 semiquantitative scoring systems proposed, none consistently predicted posttransplant outcomes across studies. Routine use of biopsies to help determine whether or not to transplant a kidney should be reexamined. In a review to determine whether routine donor kidney biopsies predict graft outcomes, the authors find little evidence for the utility of such biopsies and suggest a reexami nation of this practice.

Original languageEnglish (US)
Pages (from-to)1903-1914
Number of pages12
JournalAmerican Journal of Transplantation
Volume15
Issue number7
DOIs
StatePublished - Jul 1 2015

Keywords

  • biopsy
  • clinical research/practice
  • delayed graft function (DGF)
  • editorial/personal viewpoint
  • function/dysfunction
  • graft survival
  • kidney (allograft)
  • kidney transplantation/nephrology

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