The discriminative stimulus effects of neuropeptide Y

David C. Jewett; David W. Schaal; James Cleary; Travis Thompson; Allen S. Levine

doi:10.1016/0006-8993(91)90763-L

The discriminative stimulus effects of neuropeptide Y

David C. Jewett, David W. Schaal, James Cleary, Travis Thompson, Allen S. Levine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Neuropeptide Y (NPY), an endogenous peptide which strongly induces food intake, is demonstrated to have discriminative stimulus properties when administered intracerebroventricularly. Rats rapidly learned to press the appropriate level during training. NPY discrimination was dose-dependent. NPY's discriminative stimulus properties were compared to those of two doses of Peptide YY (PYY) and 24 and 48 h of food deprivation, conditions which also increase feeding. Both doses of PYY generalized to NPY, supporting previous findings that PYY has effects similar to NPY. Although food deprivation increases feeding in a manner similar to NPY, food deprivation did not result in NPY-appropriate responding.

Original language	English (US)
Pages (from-to)	165-168
Number of pages	4
Journal	Brain Research
Volume	561
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(91)90763-L
State	Published - Oct 4 1991

Bibliographical note

Funding Information:
This work was supported by NIDA Grant DA02717 awarded to T.T. and J.C. and NIDA Grant DA03999 awarded to A.L.D.C.J. was supported under NIDA Training Grant DA07097. The authors wish to thank Martha Grace for her expert technical assistance throughout the project.

Keywords

Discriminative stimulus
Drug discrimination
Food deprivation
Food intake
Neuropeptide Y
Peptide YY

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10.1016/0006-8993(91)90763-L

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title = "The discriminative stimulus effects of neuropeptide Y",

abstract = "Neuropeptide Y (NPY), an endogenous peptide which strongly induces food intake, is demonstrated to have discriminative stimulus properties when administered intracerebroventricularly. Rats rapidly learned to press the appropriate level during training. NPY discrimination was dose-dependent. NPY's discriminative stimulus properties were compared to those of two doses of Peptide YY (PYY) and 24 and 48 h of food deprivation, conditions which also increase feeding. Both doses of PYY generalized to NPY, supporting previous findings that PYY has effects similar to NPY. Although food deprivation increases feeding in a manner similar to NPY, food deprivation did not result in NPY-appropriate responding.",

keywords = "Discriminative stimulus, Drug discrimination, Food deprivation, Food intake, Neuropeptide Y, Peptide YY",

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note = "Funding Information: This work was supported by NIDA Grant DA02717 awarded to T.T. and J.C. and NIDA Grant DA03999 awarded to A.L.D.C.J. was supported under NIDA Training Grant DA07097. The authors wish to thank Martha Grace for her expert technical assistance throughout the project.",

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AU - Schaal, David W.

AU - Cleary, James

AU - Thompson, Travis

AU - Levine, Allen S.

N1 - Funding Information: This work was supported by NIDA Grant DA02717 awarded to T.T. and J.C. and NIDA Grant DA03999 awarded to A.L.D.C.J. was supported under NIDA Training Grant DA07097. The authors wish to thank Martha Grace for her expert technical assistance throughout the project.

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N2 - Neuropeptide Y (NPY), an endogenous peptide which strongly induces food intake, is demonstrated to have discriminative stimulus properties when administered intracerebroventricularly. Rats rapidly learned to press the appropriate level during training. NPY discrimination was dose-dependent. NPY's discriminative stimulus properties were compared to those of two doses of Peptide YY (PYY) and 24 and 48 h of food deprivation, conditions which also increase feeding. Both doses of PYY generalized to NPY, supporting previous findings that PYY has effects similar to NPY. Although food deprivation increases feeding in a manner similar to NPY, food deprivation did not result in NPY-appropriate responding.

AB - Neuropeptide Y (NPY), an endogenous peptide which strongly induces food intake, is demonstrated to have discriminative stimulus properties when administered intracerebroventricularly. Rats rapidly learned to press the appropriate level during training. NPY discrimination was dose-dependent. NPY's discriminative stimulus properties were compared to those of two doses of Peptide YY (PYY) and 24 and 48 h of food deprivation, conditions which also increase feeding. Both doses of PYY generalized to NPY, supporting previous findings that PYY has effects similar to NPY. Although food deprivation increases feeding in a manner similar to NPY, food deprivation did not result in NPY-appropriate responding.

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KW - Neuropeptide Y

KW - Peptide YY

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The discriminative stimulus effects of neuropeptide Y

Abstract

Bibliographical note

Keywords

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