The DING family of phosphate binding proteins in inflammatory diseases

Daniel Gonzalez, Mikael Elias, Eric Chabrière

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Human paraoxonase 1 (hPON-1) is a protein that has been studied in relation to its antioxidant and anti-atherosclerotic properties. Despite extensive studies, the molecular mechanisms responsible for its functional properties remain unclear. During the last decade, a new partner of hPON-1 has been identified. Hidden for a long time because of a similar molecular weight with hPON-1, this protein, termed human phosphate-binding protein (HPBP), may contribute to the biological functions of hPON-1. Belonging to the DING protein, a sub-family of phosphate binding proteins (PBP or pstS), HPBP stabilizes hPON-1 and might prevent calcification of arteries in case of advance atherosclerosis. The role of other DING proteins in some calcification processes (i.e. nephrolithiasis) and the identification of HPBP in the atheroma plaque support this hypothesis. Nevertheless, the relevance of hPON-1/HPBP as well as the molecular determinants in atherosclerosis remains to be elucidated.

Original languageEnglish (US)
Title of host publicationOxidative Stress and Inflammation in Non-Communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics
PublisherSpringer New York LLC
Pages27-32
Number of pages6
ISBN (Print)9783319073194
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume824
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • DING proteins
  • HPBP
  • Inflammation
  • Phosphate-binding proteins

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