The differential response of prostatic nucleolar and extra-nucleolar protein phosphokinase activities following androgen deprivation

Michael J Wilson, Khalil Ahmed

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Protein phosphokinase activities of nucleolar and extra-nucleolar compartments of rat ventral prostate nuclei were measured using the model acidic phosphoprotein, dephosphophosvitin, as substrate. Following orchiectomy, the activity in both of these fractions declined; however, the kinase activity of the nucleolus decreased at a much greater rate than that in the extra-nucleolar portion of the nucleus. Testosterone maintenance of castrated animals prevented this decline in activity. The regulation of protein phosphokinases which phosphorylate prostatic nucleolar acidic proteins may be an important mechanism in the androgen mediated activation of the nucleolus in this target tissue.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalEndocrine Research
Volume3
Issue number1
DOIs
StatePublished - Jan 1 1976

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