The development of oncoltyic adenovirus therapy in the past and future - For the case of pancreatic cancer

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Abstract

Pancreatic cancer is an aggressive malignant disease and the efficacy of current treatments for unresectable diseases is quite limited despite recent advances. Gene therapy/virotherapy strategies may provide new options for the treatment of various cancers including pancreatic cancer. Oncolytic adenovirus shows an antitumoral effect via its intratumoral amplification and strong cyto-cidal effect in a variety of cancers and it has been employed for the development of potent oncolytic virotherapy agents for pancreatic cancer. Our ultimate goal is to develop an oncolytic adenovirus enabling the treatment of patients with advanced or spread diseases by systemic injection. Systemic application of oncolytic therapy mandates more efficient and selective gene delivery and needs to embody sufficient antitumor effect even with limited initial delivery to the tumor location. In this review, the current status of oncolytic adenoviruses from the viewpoints of vector design and potential strategies to overcome current obstacles for its clinical application will be described. We will also discuss the efforts to improve the antitumor activity of oncolytic adenovirus, in in vivo animal models, and the combination therapy of oncolytic adenovirus with radiation and chemotherapy.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalCurrent Cancer Drug Targets
Volume18
Issue number2
DOIs
StatePublished - 2018

Bibliographical note

Funding Information:
The scientific work in this review article by our lab was partly supported by NIH/NCIR01CA196215 and CA168448.

Funding Information:
The scientific work in this review article by our lab was partly supported by NIH/NCI R01CA196215 and CA168448.

Publisher Copyright:
© 2018 Bentham Science Publishers.

Keywords

  • Adenovirus library screening
  • Cox-2 promoter
  • Fiber-modified Ad
  • Oncolytic adenovirus
  • Pancreatic cancer

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