The designed angiostatic peptide anginex synergistically improves chemotherapy and antiangiogenesis therapy with angiostatin

Ruud P M Dings, Yumi Yokoyama, Sundaram Ramakrishnan, Arjan W. Griffioen, Kevin H Mayo

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

Recently, we demonstrated that the designed peptide anginex displays potent antiangiogenic activity. The aim of the present study was to investigate anginex treatment as a single-agent therapy and to test its ability to improve conventional chemotherapy and antiangiogenesis therapy. In a human ovarian carcinoma mouse model, anginex inhibited tumor growth by 70%. When anginex was combined with a suboptimal dose of carboplatin, tumors regressed to an impalpable state. Anginex plus angiostatin worked synergistically to inhibit tumor growth. Assessment of microvessel density suggested that the antitumor activity of anginex is mediated by angiogenesis inhibition. In any of the experiments, no sign of anginexinduced toxicity was observed.

Original languageEnglish (US)
Pages (from-to)382-385
Number of pages4
JournalCancer Research
Volume63
Issue number2
StatePublished - Jan 15 2003

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