The design of peptide-amphiphiles as functional ligands for liposomal anticancer drug and gene delivery

Huihui Kuang, Sook Hee Ku, Efrosini Kokkoli

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Liposomal nanomedicine has led to clinically useful cancer therapeutics like Doxil and DaunoXome. In addition, peptide-functionalized liposomes represent an effective drug and gene delivery vehicle with increased cancer cell specificity, enhanced tumor-penetrating ability and high tumor growth inhibition. The goal of this article is to review the recently published literature of the peptide-amphiphiles that were used to functionalize liposomes, to highlight successful designs that improved drug and gene delivery to cancer cells in vitro, and cancer tumors in vivo, and to discuss the current challenges of designing these peptide-decorated liposomes for effective cancer treatment.

Original languageEnglish (US)
Pages (from-to)80-101
Number of pages22
JournalAdvanced Drug Delivery Reviews
Volume110-111
DOIs
StatePublished - Feb 2017

Keywords

  • CPP
  • Liposomes
  • Nanoparticles
  • PEG
  • Stimuli-responsive
  • Targeted drug delivery
  • Targeted gene delivery

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