Abstract
Naltrexone-derived antagonists which are highly selective for δ opioid receptors have been designed using the message-address concept. The prototypical member of this series, naltrindole 1, possesses very high affinity and selectivity for δ receptors, and a closely related benzofuran analogue, NTB 2, is a selective δ2 antagonist. The fact that 7-benzylidenenaltrexone (BNTX) was found to be a δ1 antagonist suggests that the conformation of the putative δ address component (phenyl group) of BNTX plays a role in modulating δ subtype selectivity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 243-251 |
| Number of pages | 9 |
| Journal | Farmaco |
| Volume | 48 |
| Issue number | 2 |
| State | Published - Jan 1 1993 |