The design and evaluation of hybrid controlled trials that leverage external data and randomization

Keyphrases

• Clinical Trial Design 50%
• Clinical Trials 50%
• Control Arm 50%
• Efficient Inference 50%
• Electronic Health Records 50%
• Experimental Therapeutics 100%
• Extensive-stage Small Cell Lung Cancer (ES-SCLC) 50%
• External Control 50%
• External Data 100%
• Glioblastoma 50%
• Hybrid Trial 100%
• Patient Characteristics 50%
• Patient-level Data 50%
• Potential Confounders 50%
• Randomized Trial Design 50%
• Statistical Design 50%
• Treatment Effect 50%
• Trial Design 100%

Mathematics

• Confounders 25%
• Experimental Treatment 50%
• Randomized Trial 25%
• Statistical Design 25%
• Treatment Effect 25%
• Trial Design 100%

Biochemistry, Genetics and Molecular Biology

• Clinical Study 100%
• Clinical Trial 50%
• Clinical Trial Design 50%
• Electronic Health Record 50%