The delta2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference

S. Krishnan-Sarin, P. S. Portoghese, T. K. Li, J. C. Froehlich

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


The relative importance of different opioid receptor types in mediating alcohol drinking behavior compared with the intake of other ingesta can be determined by characterizing the effects of selective opioid antagonists on the intake of various ingesta. Nonselective opioid receptor antagonists suppress the intake of many ingesta including alcohol, food, water, and sweets. Two distinct subtypes of delta-opioid receptors, delta1 and delta2, have recently been identified in rodent brain. We have previously reported that naltrindole (NTI), which blocks both delta1 and delta2 receptors, suppresses both alcohol and saccharin intake in rats selectively bred for high alcohol preference (P line). We now report that naltriben (NTB), an opioid antagonist that is selective for delta2-opioid receptors, suppresses alcohol intake in rats of the P Une and the effect appears to be both specific for alcohol and independent of alcohol palatability. NTB may reduce alcohol intake by attenuating the reinforcing pharmacological properties of alcohol.

Original languageEnglish (US)
Pages (from-to)153-159
Number of pages7
JournalPharmacology, Biochemistry and Behavior
Issue number1
StatePublished - Sep 1995

Bibliographical note

Funding Information:
We thank Dr. JamesN orton for statisticalc onsultation.T his researchw as supported,i n part, by grants AA08312 AAO8553, AA07611 , and DA01533fr om the PHS.


  • Alcohol drinking
  • Alcohol palatability
  • Naltriben
  • Opioid receptor antagonists
  • Selectively bred rat lines


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