The current state of long-Acting growth hormone preparations for growth hormone therapy

Kevin C.J. Yuen, Bradley S. Miller, Beverly M.K. Biller

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Purpose of review To discuss the rationale of developing long-Acting growth hormone (LAGH) preparations, to describe the technologies designed to prolong GH action, and to address key issues regarding efficacy, safety, and monitoring while on treatment. Review findings Recombinant human GH is currently approved for daily use and has been shown to restore longitudinal growth, and improve body composition with relatively few side-effects in children and adults with GH deficiency, respectively. However, daily injections can be inconvenient, painful and distressing for some patients, resulting in decreased adherence and efficacy. Over a dozen pharmaceutical companies have designed LAGH preparations that are at various stages of development using a number of different methods to prolong GH action. Summary LAGH will represent an advancement over daily recombinant human GH injections because of fewer injections that may offer increased acceptance, tolerability, and therapeutic flexibility to patients that potentially can improve treatment outcomes. However, given the unphysiological profile of LAGH preparations, long-Term surveillance of efficacy and safety are needed. This review summarizes recent developments of LAGH preparations, and highlights the importance of long-Term surveillance registries to assess for efficacy and safety that will be essential for understanding the impact of prolonged exposure to these compounds.

Original languageEnglish (US)
Pages (from-to)267-273
Number of pages7
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Issue number4
StatePublished - Aug 1 2018

Bibliographical note

Publisher Copyright:
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.


  • adults
  • children
  • growth hormone deficiency
  • growth hormone replacement
  • long-Acting growth hormone
  • treatment adherence


Dive into the research topics of 'The current state of long-Acting growth hormone preparations for growth hormone therapy'. Together they form a unique fingerprint.

Cite this