The complex interplay between mitochondrial dynamics and cardiac metabolism

Valentina Parra, Hugo Verdejo, Andrea Del Campo, Christian Pennanen, Jovan Kuzmicic, Myriam Iglewski, Joseph A. Hill, Beverly A. Rothermel, Sergio Lavandero

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Mitochondria are highly dynamic organelles, capable of undergoing constant fission and fusion events, forming networks. These dynamic events allow the transmission of chemical and physical messengers and the exchange of metabolites within the cell. In this article we review the signaling mechanisms controlling mitochondrial fission and fusion, and its relationship with cell bioenergetics, especially in the heart. Furthermore we also discuss how defects in mitochondrial dynamics might be involved in the pathogenesis of metabolic cardiac diseases.

Original languageEnglish (US)
Pages (from-to)47-51
Number of pages5
JournalJournal of Bioenergetics and Biomembranes
Volume43
Issue number1
DOIs
StatePublished - Feb 2011

Bibliographical note

Funding Information:
Acknowledgments This research was funded in part by the Comision Nacional de Ciencia y Tecnologia (FONDECYT 1080436 and FONDAP 15010006 to S.L.), the National Institutes of Health (RO1HL090842, RO1HL080144 and RO1 HL0755173 to J.A.H. and RO1HL072016 and RO1HL097768 to B.A.R.), the American Heart Association (10POST4340064 to M.I., 0640084N to J.A.H., and Gran-in-Aid #0655202Y to B.A.R.), the American Heart Association-Jon Holden DeHaan Foundation (to J.A.H. and B.A.R.). V.P., H.V., J.K., C.P., A.d.C. hold a PhD fellowship from CONICYT, Chile.

Keywords

  • Fission
  • Fusion
  • Heart
  • Metabolism
  • Mitochondria
  • Mitochondrial dynamics

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