The comparison of the performance of 3 T and 7 T T2 mapping for untreated low-grade cartilage lesions

Vladimir Juras, Markus Schreiner, Didier Laurent, Stefan Zbyn, Vladimir Mlynarik, Pavol Szomolanyi, Benedikt Hager, Celeste Scotti, Jörg Goldhahn, Rahel Heule, Oliver Bieri, Siegfried Trattnig

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To investigate T2 mapping as a possible marker for low-grade human articular cartilage lesions during a one-year follow-up, possible changes during the follow-up and compare the reliability and sensitivity of these measurements on high-field (3 T) and ultra-high-field (7 T) MRI scanners. Design: Twenty-one patients with femoral, tibial and patellar cartilage defect in the knee joint participated in the study. The MRI protocol consisted of morphological, as well as three-dimensional triple-echo steady-state (3D-TESS) T2 mapping sequences with similar parameters at 3T and 7T. Patients were scanned at five time-points up to 12 months. T2 values were evaluated in the lesion and healthy-appearing regions for superficial and deep cartilage zone. The repeated ANOVA was used to determine differences in T2 values at various time points. Results: A significant decrease in T2 values was observed between baseline and six months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 31.21 ± 7.2 ms, which is a difference of −5.67 ± 2.2 ms (p = 0.031)), and at 12 months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 35.28 ± 4.9 ms, which is a difference of −6.60 ± 4.4 ms (p = 0.044). No significant differences were recorded at 7 T. Conclusion: The change in T2 values acquired with 3 T 3D-TESS appears to be reflecting subtle changes of cartilage composition in the course of low-grade lesion development. 7 T T2 mapping does not reflect these changes probably due to completely decayed short T2 component.

Original languageEnglish (US)
Pages (from-to)86-92
Number of pages7
JournalMagnetic Resonance Imaging
Volume55
DOIs
StatePublished - Jan 1 2019

Fingerprint

Cartilage
Magnetic resonance imaging
Articular Cartilage
Knee Joint
Analysis of variance (ANOVA)
Thigh
Analysis of Variance
Defects
Chemical analysis

Keywords

  • 3 T
  • 7 T
  • Low grade cartilage lesion
  • T mapping
  • TESS

PubMed: MeSH publication types

  • Comparative Study
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

The comparison of the performance of 3 T and 7 T T2 mapping for untreated low-grade cartilage lesions. / Juras, Vladimir; Schreiner, Markus; Laurent, Didier; Zbyn, Stefan; Mlynarik, Vladimir; Szomolanyi, Pavol; Hager, Benedikt; Scotti, Celeste; Goldhahn, Jörg; Heule, Rahel; Bieri, Oliver; Trattnig, Siegfried.

In: Magnetic Resonance Imaging, Vol. 55, 01.01.2019, p. 86-92.

Research output: Contribution to journalArticle

Juras, V, Schreiner, M, Laurent, D, Zbyn, S, Mlynarik, V, Szomolanyi, P, Hager, B, Scotti, C, Goldhahn, J, Heule, R, Bieri, O & Trattnig, S 2019, 'The comparison of the performance of 3 T and 7 T T2 mapping for untreated low-grade cartilage lesions', Magnetic Resonance Imaging, vol. 55, pp. 86-92. https://doi.org/10.1016/j.mri.2018.09.021
Juras, Vladimir ; Schreiner, Markus ; Laurent, Didier ; Zbyn, Stefan ; Mlynarik, Vladimir ; Szomolanyi, Pavol ; Hager, Benedikt ; Scotti, Celeste ; Goldhahn, Jörg ; Heule, Rahel ; Bieri, Oliver ; Trattnig, Siegfried. / The comparison of the performance of 3 T and 7 T T2 mapping for untreated low-grade cartilage lesions. In: Magnetic Resonance Imaging. 2019 ; Vol. 55. pp. 86-92.
@article{640ec90b67404209883c9026f69aed53,
title = "The comparison of the performance of 3 T and 7 T T2 mapping for untreated low-grade cartilage lesions",
abstract = "Objective: To investigate T2 mapping as a possible marker for low-grade human articular cartilage lesions during a one-year follow-up, possible changes during the follow-up and compare the reliability and sensitivity of these measurements on high-field (3 T) and ultra-high-field (7 T) MRI scanners. Design: Twenty-one patients with femoral, tibial and patellar cartilage defect in the knee joint participated in the study. The MRI protocol consisted of morphological, as well as three-dimensional triple-echo steady-state (3D-TESS) T2 mapping sequences with similar parameters at 3T and 7T. Patients were scanned at five time-points up to 12 months. T2 values were evaluated in the lesion and healthy-appearing regions for superficial and deep cartilage zone. The repeated ANOVA was used to determine differences in T2 values at various time points. Results: A significant decrease in T2 values was observed between baseline and six months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 31.21 ± 7.2 ms, which is a difference of −5.67 ± 2.2 ms (p = 0.031)), and at 12 months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 35.28 ± 4.9 ms, which is a difference of −6.60 ± 4.4 ms (p = 0.044). No significant differences were recorded at 7 T. Conclusion: The change in T2 values acquired with 3 T 3D-TESS appears to be reflecting subtle changes of cartilage composition in the course of low-grade lesion development. 7 T T2 mapping does not reflect these changes probably due to completely decayed short T2 component.",
keywords = "3 T, 7 T, Low grade cartilage lesion, T mapping, TESS",
author = "Vladimir Juras and Markus Schreiner and Didier Laurent and Stefan Zbyn and Vladimir Mlynarik and Pavol Szomolanyi and Benedikt Hager and Celeste Scotti and J{\"o}rg Goldhahn and Rahel Heule and Oliver Bieri and Siegfried Trattnig",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.mri.2018.09.021",
language = "English (US)",
volume = "55",
pages = "86--92",
journal = "Magnetic Resonance Imaging",
issn = "0730-725X",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - The comparison of the performance of 3 T and 7 T T2 mapping for untreated low-grade cartilage lesions

AU - Juras, Vladimir

AU - Schreiner, Markus

AU - Laurent, Didier

AU - Zbyn, Stefan

AU - Mlynarik, Vladimir

AU - Szomolanyi, Pavol

AU - Hager, Benedikt

AU - Scotti, Celeste

AU - Goldhahn, Jörg

AU - Heule, Rahel

AU - Bieri, Oliver

AU - Trattnig, Siegfried

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: To investigate T2 mapping as a possible marker for low-grade human articular cartilage lesions during a one-year follow-up, possible changes during the follow-up and compare the reliability and sensitivity of these measurements on high-field (3 T) and ultra-high-field (7 T) MRI scanners. Design: Twenty-one patients with femoral, tibial and patellar cartilage defect in the knee joint participated in the study. The MRI protocol consisted of morphological, as well as three-dimensional triple-echo steady-state (3D-TESS) T2 mapping sequences with similar parameters at 3T and 7T. Patients were scanned at five time-points up to 12 months. T2 values were evaluated in the lesion and healthy-appearing regions for superficial and deep cartilage zone. The repeated ANOVA was used to determine differences in T2 values at various time points. Results: A significant decrease in T2 values was observed between baseline and six months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 31.21 ± 7.2 ms, which is a difference of −5.67 ± 2.2 ms (p = 0.031)), and at 12 months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 35.28 ± 4.9 ms, which is a difference of −6.60 ± 4.4 ms (p = 0.044). No significant differences were recorded at 7 T. Conclusion: The change in T2 values acquired with 3 T 3D-TESS appears to be reflecting subtle changes of cartilage composition in the course of low-grade lesion development. 7 T T2 mapping does not reflect these changes probably due to completely decayed short T2 component.

AB - Objective: To investigate T2 mapping as a possible marker for low-grade human articular cartilage lesions during a one-year follow-up, possible changes during the follow-up and compare the reliability and sensitivity of these measurements on high-field (3 T) and ultra-high-field (7 T) MRI scanners. Design: Twenty-one patients with femoral, tibial and patellar cartilage defect in the knee joint participated in the study. The MRI protocol consisted of morphological, as well as three-dimensional triple-echo steady-state (3D-TESS) T2 mapping sequences with similar parameters at 3T and 7T. Patients were scanned at five time-points up to 12 months. T2 values were evaluated in the lesion and healthy-appearing regions for superficial and deep cartilage zone. The repeated ANOVA was used to determine differences in T2 values at various time points. Results: A significant decrease in T2 values was observed between baseline and six months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 31.21 ± 7.2 ms, which is a difference of −5.67 ± 2.2 ms (p = 0.031)), and at 12 months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 35.28 ± 4.9 ms, which is a difference of −6.60 ± 4.4 ms (p = 0.044). No significant differences were recorded at 7 T. Conclusion: The change in T2 values acquired with 3 T 3D-TESS appears to be reflecting subtle changes of cartilage composition in the course of low-grade lesion development. 7 T T2 mapping does not reflect these changes probably due to completely decayed short T2 component.

KW - 3 T

KW - 7 T

KW - Low grade cartilage lesion

KW - T mapping

KW - TESS

UR - http://www.scopus.com/inward/record.url?scp=85053835870&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053835870&partnerID=8YFLogxK

U2 - 10.1016/j.mri.2018.09.021

DO - 10.1016/j.mri.2018.09.021

M3 - Article

C2 - 30244140

AN - SCOPUS:85053835870

VL - 55

SP - 86

EP - 92

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

ER -