The comparison of the performance of 3 T and 7 T T2 mapping for untreated low-grade cartilage lesions

Vladimir Juras, Markus Schreiner, Didier Laurent, Štefan Zbýň, Vladimir Mlynarik, Pavol Szomolanyi, Benedikt Hager, Celeste Scotti, Jörg Goldhahn, Rahel Heule, Oliver Bieri, Siegfried Trattnig

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7 Scopus citations

Abstract

Objective: To investigate T2 mapping as a possible marker for low-grade human articular cartilage lesions during a one-year follow-up, possible changes during the follow-up and compare the reliability and sensitivity of these measurements on high-field (3 T) and ultra-high-field (7 T) MRI scanners. Design: Twenty-one patients with femoral, tibial and patellar cartilage defect in the knee joint participated in the study. The MRI protocol consisted of morphological, as well as three-dimensional triple-echo steady-state (3D-TESS) T2 mapping sequences with similar parameters at 3T and 7T. Patients were scanned at five time-points up to 12 months. T2 values were evaluated in the lesion and healthy-appearing regions for superficial and deep cartilage zone. The repeated ANOVA was used to determine differences in T2 values at various time points. Results: A significant decrease in T2 values was observed between baseline and six months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 31.21 ± 7.2 ms, which is a difference of −5.67 ± 2.2 ms (p = 0.031)), and at 12 months in the superficial layer of the lesion in patients at 3 T (decrease from 41.89 ± 9.3 ms to 35.28 ± 4.9 ms, which is a difference of −6.60 ± 4.4 ms (p = 0.044). No significant differences were recorded at 7 T. Conclusion: The change in T2 values acquired with 3 T 3D-TESS appears to be reflecting subtle changes of cartilage composition in the course of low-grade lesion development. 7 T T2 mapping does not reflect these changes probably due to completely decayed short T2 component.

Original languageEnglish (US)
Pages (from-to)86-92
Number of pages7
JournalMagnetic Resonance Imaging
Volume55
DOIs
StatePublished - Jan 2019

Bibliographical note

Funding Information:
The authors would like to thank Harry Haber for his help with statistics. This work was supported by the NOVARTIS PHARMA AG PJMR0062112 , Austrian Science Fund (FWF) KLI541-B30 and Slovak Grant Agency APVV-0431-12 .

Funding Information:
The authors would like to thank Harry Haber for his help with statistics. This work was supported by the NOVARTIS PHARMA AG PJMR0062112, Austrian Science Fund (FWF) KLI541-B30 and Slovak Grant Agency APVV-0431-12.

Keywords

  • 3 T
  • 7 T
  • Low grade cartilage lesion
  • T mapping
  • TESS

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