The comparison between CHOP and R-CHOP in primary gastric diffuse large B cell lymphoma

Byeong Seok Sohn, Sun Mok Kim, Dok Hyun Yoon, Shin Kim, Dae Ho Lee, Jin Ho Kim, Sang Wook Lee, Jooryung Huh, Cheolwon Suh

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26 Scopus citations

Abstract

The combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) plus rituximab is the standard treatment for patients with primary gastric diffuse large B cell lymphoma (DLBCL). However, a few trials comparing CHOP plus rituximab (RCHOP) with CHOP have been conducted in primary gastric DLBCL. Among 93 consecutive patients receiving CHOP or R-CHOP as a first-line chemotherapy at our institution, 38 patients received CHOP and 55 patients received R-CHOP. With a median follow-up time of 48 months, the complete response (CR) rate, event-free survival (EFS), and overall survival (OS) did not differ between two treatment groups (P=1.000, P=0.744, and P=0.213, respectively). The CR rates were 93.9 % for patients receiving CHOP and 92.5 % for patients receiving R-CHOP. The 3-year EFS rates were 86.0 % for patients receiving CHOP and 81.7 % for patients receiving R-CHOP; the 3-year OS rates were 94.7 and 84.7%, respectively. In a multivariate analysis, The CR rate was affected by the number of extranodal involvements (P= 0.011). The EFS and OS rates were affected by the Lugano stage (P=0.067 and P=0.008, respectively). High serum level of β2-microglobulin was associated with worse EFS and OS in patients receiving R-CHOP (P=0.018 and P=0.015, respectively). In conclusion, the addition of rituximab was not found to have an impact on patients' outcomes with primary gastric DLBCL. The β2- microglobulin in primary gastric DLBCL might be able to discriminate the patients' prognosis who are treated with R-CHOP chemotherapy.

Original languageEnglish (US)
Pages (from-to)1731-1739
Number of pages9
JournalAnnals of hematology
Volume91
Issue number11
DOIs
StatePublished - Nov 1 2012

Keywords

  • Primary gastric diffuse large B cell lymphoma
  • Prognosis
  • Rituximab . β-microglobulin

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    Sohn, B. S., Kim, S. M., Yoon, D. H., Kim, S., Lee, D. H., Kim, J. H., Lee, S. W., Huh, J., & Suh, C. (2012). The comparison between CHOP and R-CHOP in primary gastric diffuse large B cell lymphoma. Annals of hematology, 91(11), 1731-1739. https://doi.org/10.1007/s00277-012-1512-4