TY - JOUR
T1 - The comparison between CHOP and R-CHOP in primary gastric diffuse large B cell lymphoma
AU - Sohn, Byeong Seok
AU - Kim, Sun Mok
AU - Yoon, Dok Hyun
AU - Kim, Shin
AU - Lee, Dae Ho
AU - Kim, Jin Ho
AU - Lee, Sang Wook
AU - Huh, Jooryung
AU - Suh, Cheolwon
PY - 2012/11
Y1 - 2012/11
N2 - The combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) plus rituximab is the standard treatment for patients with primary gastric diffuse large B cell lymphoma (DLBCL). However, a few trials comparing CHOP plus rituximab (RCHOP) with CHOP have been conducted in primary gastric DLBCL. Among 93 consecutive patients receiving CHOP or R-CHOP as a first-line chemotherapy at our institution, 38 patients received CHOP and 55 patients received R-CHOP. With a median follow-up time of 48 months, the complete response (CR) rate, event-free survival (EFS), and overall survival (OS) did not differ between two treatment groups (P=1.000, P=0.744, and P=0.213, respectively). The CR rates were 93.9 % for patients receiving CHOP and 92.5 % for patients receiving R-CHOP. The 3-year EFS rates were 86.0 % for patients receiving CHOP and 81.7 % for patients receiving R-CHOP; the 3-year OS rates were 94.7 and 84.7%, respectively. In a multivariate analysis, The CR rate was affected by the number of extranodal involvements (P= 0.011). The EFS and OS rates were affected by the Lugano stage (P=0.067 and P=0.008, respectively). High serum level of β2-microglobulin was associated with worse EFS and OS in patients receiving R-CHOP (P=0.018 and P=0.015, respectively). In conclusion, the addition of rituximab was not found to have an impact on patients' outcomes with primary gastric DLBCL. The β2- microglobulin in primary gastric DLBCL might be able to discriminate the patients' prognosis who are treated with R-CHOP chemotherapy.
AB - The combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) plus rituximab is the standard treatment for patients with primary gastric diffuse large B cell lymphoma (DLBCL). However, a few trials comparing CHOP plus rituximab (RCHOP) with CHOP have been conducted in primary gastric DLBCL. Among 93 consecutive patients receiving CHOP or R-CHOP as a first-line chemotherapy at our institution, 38 patients received CHOP and 55 patients received R-CHOP. With a median follow-up time of 48 months, the complete response (CR) rate, event-free survival (EFS), and overall survival (OS) did not differ between two treatment groups (P=1.000, P=0.744, and P=0.213, respectively). The CR rates were 93.9 % for patients receiving CHOP and 92.5 % for patients receiving R-CHOP. The 3-year EFS rates were 86.0 % for patients receiving CHOP and 81.7 % for patients receiving R-CHOP; the 3-year OS rates were 94.7 and 84.7%, respectively. In a multivariate analysis, The CR rate was affected by the number of extranodal involvements (P= 0.011). The EFS and OS rates were affected by the Lugano stage (P=0.067 and P=0.008, respectively). High serum level of β2-microglobulin was associated with worse EFS and OS in patients receiving R-CHOP (P=0.018 and P=0.015, respectively). In conclusion, the addition of rituximab was not found to have an impact on patients' outcomes with primary gastric DLBCL. The β2- microglobulin in primary gastric DLBCL might be able to discriminate the patients' prognosis who are treated with R-CHOP chemotherapy.
KW - Primary gastric diffuse large B cell lymphoma
KW - Prognosis
KW - Rituximab . β-microglobulin
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U2 - 10.1007/s00277-012-1512-4
DO - 10.1007/s00277-012-1512-4
M3 - Article
C2 - 22752193
AN - SCOPUS:84867333245
VL - 91
SP - 1731
EP - 1739
JO - Annals of Hematology
JF - Annals of Hematology
SN - 0939-5555
IS - 11
ER -